Active Recombinant Human MSLN Protein
Cat.No. : | MSLN-8392H |
Product Overview : | Recombinant human MSLN is expressed as a 317-amino acid protein consisting of Glu296 - Ser592 region of MSLN (UniProt accession #Q13421, isoform 2) and a C-terminal His-tag. It contains 4 potential N-linked glycosylation sites. |
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Source : | Human cells |
Species : | Human |
Bio-activity : | Binds to CA125/MUC16 and anti-MSLN monoclonal antibody, human IgG1 with high affinity KD < 5 nM as measured by ELISA. |
Molecular Mass : | Calculated molecular mass (kDa): 35.9; Estimated by SDS-PAGE under reducing condition (kDa): 48-50 |
AA Sequence : | EVEKTACPSGKKAREIDESLIFYKK WELEACVDAALLATQMDRVNAIPFT YEQLDVLKHKLDELYPQGYPESVIQ HLGYLFLKMSPEDIRKWNVTSLETL KALLEVNKGHEMSPQVATLIDRFVK GRGQLDKDTLDTLTAFYPGYLCSLS PEELSSVPPSSIWAVRPQDLDTCDP RQLDVLYPKARLAFQNMNGSEYFVK IQSFLGGAPTEDLKALSQQNVSMDL ATFMKLRTDAVLPLTVAEVQKLLGP HVEGLKAEERHRPVRDWILRQRQDD LDTLGLGLQGGIPNGYLVLDLSTTE NLYFQGSTGHHHHHHHH |
Endotoxin : | <0.1 EU per 1 μg of purified recombinant protein determined by the LAL method |
Purity : | >90% judged by SDS-PAGE under reducing condition. |
Storage : | The product is shipped at 4 centigrade. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20 centigrade for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4 centigrade for no more than 2 weeks. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). |
Warning : | FOR RESEARCH USE ONLY. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE IN HUMAN. |
Gene Name : | MSLN |
Official Symbol : | MSLN mesothelin [ Homo sapiens (human) ] |
Synonyms : | MSLN; MPF; SMRP; CAK1; mesothelin; mesothelin; CAK1 antigen; megakaryocyte potentiating factor; pre-pro-megakaryocyte-potentiating factor; soluble MPF mesothelin related protein |
Gene ID : | 10232 |
mRNA Refseq : | NM_001177355 |
Protein Refseq : | NP_001170826 |
MIM : | 601051 |
UniProt ID : | Q13421 |
Products Types
◆ Recombinant Protein | ||
Msln-4191M | Active Recombinant Mouse Msln Protein, His-tagged | +Inquiry |
MSLN-5659H | Recombinant Human MSLN Protein, GST-tagged | +Inquiry |
MSLN-1139H | Recombinant Human MSLN Protein, His-tagged | +Inquiry |
MSLN-2092H | Recombinant Human MSLN Protein, MYC/DDK-tagged | +Inquiry |
MSLN-317H | Active Recombinant Human MSLN Protein (Glu 296 - Gly 580), His-tagged, GFP Fusion | +Inquiry |
◆ Lysates | ||
MSLN-1316HCL | Recombinant Human MSLN cell lysate | +Inquiry |
MSLN-1343HCL | Recombinant Human MSLN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.
In cancer, MSLN expression is significantly upregulated.
MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.
Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.
MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.
MSLN overexpression is often associated with poor prognosis in cancer patients.
MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.
Customer Reviews (3)
Write a reviewVery satisfied, great product.
Product is high-quality.
Excellent for experiments, reliable.
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