Recombinant Human MTHFD1L Protein, GST-tagged

• Cat.No.: MTHFD1L-5703H
• Product Overview: Human MTHFD1L full-length ORF ( AAH08629.1, 1 a.a. - 366 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: One-carbon substituted forms of tetrahydrofolate (THF) are involved in the de novo synthesis of purines and thymidylate and support cellular methylation reactions through the regeneration of methionine from homocysteine. MTHFD1L is an enzyme involved in THF synthesis in mitochondria (Christensen et al., 2005 [PubMed 15611115]).[supplied by OMIM
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 65.6 kDa
• AA Sequence: MAVLALTDSLADMKARLGRMVVASD KSGQPVTADDLGVTGALTVLMKDAI KPNLMQTLEGTPVFVHAGPFANIAH GNSSVLADKIALKLVGEEGFVVTEA GFGADIGMEKFFNIKCRASGLVPNV VVLVATVRALKMHGGGPSVTAGVPL KKEYTEENIQLVADGCCNLQKQIQI TQLFGVPVVVALNVFKTDTRAEIDL VCELAKRAGAFDAVPCYHWSVGGKG SVDLARAVREAASKRSRFQFLYDVQ VPIVDKIRTIAQAVYGAKDIELSPE AQAKIDRYTQQGFGNLPICMAKTHL SLSHQPDKKGVPRDFILPISDVRAS IGAGFIYPLVGTMSTMPGLPTRPCF YDIDLDTETEQVKGLF
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like [ Homo sapiens ]
• Official Symbol: MTHFD1L
• Synonyms: MTHFD1L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; formyltetrahydrofolate synthetase domain containing 1 , FTHFSDC1; monofunctional C1-tetrahydrofolate synthase, mitochondrial; 10 formyl THF synthetase; DKFZP586G1517; FLJ21145; mitochondrial C1 tetrahydrofolate synthase; monofunctional C1 tetrahydrofolate synthase; mitochondrial; 10-formyl-THF synthetase; formyltetrahydrofolate synthetase domain containing 1; FTHFSDC1; MTC1THFS; dJ292B18.2; RP1-292B18.2; DKFZp586G1517
• Gene ID: 25902
• mRNA Refseq: NM_001242767
• Protein Refseq: NP_001229696
• MIM: 611427
• UniProt ID: Q6UB35