Recombinant Human NAGPA Protein, MYC/DDK-tagged

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Recombinant Human NAGPA Protein, MYC/DDK-tagged

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Cat.No. : NAGPA-189H
Product Overview : Recombinant human NAGPA protein, fused to MYC/DDK-tag at C-terminal, was expressed in HEK293.
Description : Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients. [provided by RefSeq, Oct 2015].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 53.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [ Homo sapiens ]
Official Symbol : NAGPA
Synonyms : APAA; UCE
Gene ID : 51172
mRNA Refseq : NM_016256.3
Protein Refseq : NP_057340.2
MIM : 607985
UniProt ID : Q9UK23

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