Recombinant Human NECAB3 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: NECAB3-3455H
• Product Overview: NECAB3 MS Standard C13 and N15-labeled recombinant protein (NP_112508) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 40.8 kDa
• AA Sequence: MACAGLLTVCLLRPPAPQPQPQTPR HPQLAPDPGPAGHTLFQDVFRRADK NDDGKLSFEEFQNYFADGVLSLGEL QELFSGIDGHLTDNLETEKLCDYFS EHLGVYRPVLAALESLNRAVLAAMD ATKLEYERASKVDQFVTRFLLRETV SQLQALQSSLEGASDTLEAQAHGWR SDAESVEAQSRLCGSRRAGRRALRS VSRSSTWSPGSSDTGRSSEAEMQWR LQVNRLQELIDQLECKAPRLEPLRE EDLAKGPDLHILMAQRQVQVAEEGL QDFHRALRCYVDFTGAQSHCLHVSA QKMLDGASFTLYEFWQDEASWRRHQ QSPGSKAFQRILIDHLRAPDTLTTV FFPASWWIMNNNTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: NECAB3 N-terminal EF-hand calcium binding protein 3 [ Homo sapiens (human) ]
• Official Symbol: NECAB3
• Synonyms: NECAB3; N-terminal EF-hand calcium binding protein 3; amyloid beta (A4) precursor protein binding, family A, member 2 binding protein, APBA2BP, SYTIP2; N-terminal EF-hand calcium-binding protein 3; dJ63M2.4; dJ63M2.5; EF hand calcium binding protein 3; EFCBP3; NIP1; XB51; X11L-binding protein 51; Nek2-interacting protein 1; EF-hand calcium binding protein 3; neuronal calcium-binding protein 3; synaptotagmin interacting protein 2; neuronal calcium-binding protein NECAB3; synaptotagmin interacting protein STIP3; amyloid beta A4 protein-binding family A member 2-binding protein; amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein; STIP3; SYTIP2; APBA2BP
• Gene ID: 63941
• mRNA Refseq: NM_031231
• Protein Refseq: NP_112508
• MIM: 612478
• UniProt ID: Q96P71