Recombinant Human NLRP10 Protein, Myc/DDK-tagged, C13 and N15-labeled NLRP10-5638H

Specification Gene Information Related Products

Cat.No. :	NLRP10-5638H
Product Overview :	NLRP10 MS Standard C13 and N15-labeled recombinant protein (NP_789791) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description :	Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.
Source :	HEK293
Species :	Human
Tag :	Myc/DDK
Molecular Mass :	75 kDa
AA Sequence :	MAMAKARKPR EALLWALSDL EENDFKKLKF YLRDMTLSEG QPPLARGELE GLIPVDLAEL LISKYGEKEA VKVVLKGLKV MNLLELVDQL SHICLHDYRE VYREHVRCLE EWQEAGVNGR YNQVLLVAKP SSESPESLAC PFPEQELESV TVEALFDSGE KPSLAPSLVV LQGSAGTGKT TLARKMVLDW ATGTLYPGRF DYVFYVSCKE VVLLLESKLE QLLFWCCGDN QAPVTEILRQ PERLLFILDG FDELQRPFEE KLKKRGLSPK ESLLHLLIRR HTLPTCSLLI TTRPLALRNL EPLLKQARHV HILGFSEEER ARYFSSYFTD EKQADRAFDI VQKNDILYKA CQVPGICWVV CSWLQGQMER GKVVLETPRN STDIFMAYVS TFLPPDDDGG CSELSRHRVL RSLCSLAAEG IQHQRFLFEE AELRKHNLDG PRLAAFLSSN DYQLGLAIKK FYSFRHISFQ DFFHAMSYLV KEDQSRLGKE SRREVQRLLE VKEQEGNDEM TLTMQFLLDI SKKDSFSNLE LKFCFRISPC LAQDLKHFKE QMESMKHNRT WDLEFSLYEA KIKNLVKGIQ MNNVSFKIKH SNEKKSQSQN LFSVKSSLSH GPKEEQKCPS VHGQKEGKDN IAGTQKEAST GKGRGTEETP KNTYITRTRP LEQKLISEED LAANDILDYK DDDDKV
Purity :	> 80% as determined by SDS-PAGE and Coomassie blue staining
Stability :	Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage :	Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration :	50 μg/mL as determined by BCA
Storage Buffer :	100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name :	NLRP10 NLR family pyrin domain containing 10 [ Homo sapiens (human) ]
Official Symbol :	NLRP10
Synonyms :	NLRP10; NLR family, pyrin domain containing 10; NACHT, leucine rich repeat and PYD containing 10, NALP10; NACHT, LRR and PYD domains-containing protein 10; CLR11.1; NOD8; nucleotide binding oligomerization domain; leucine rich repeat and pyrin domain containing 10; PAN5; Pynod; NACHT, leucine rich repeat and PYD containing 10; nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10; PYNOD; NALP10;
Gene ID :	338322
mRNA Refseq :	NM_176821
Protein Refseq :	NP_789791
MIM :	609662
UniProt ID :	Q86W26