"NTN1" Related Products

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Recombinant Human NTN1 Protein, FLAG-tagged

Cat.No.: NTN1-22H
Product Overview: Recombinant Human netrin-1 (aa 25-604) protein fused with C-terminus FLAG-tag was expressed in HEK293 cell.
Description: Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.
Source: HEK 293
Species: Human
Tag : FLAG
Form: Lyophilized
Bio-activity: Induces pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by inhibiting apoptosis mediated by the receptors DCC or UNC5B (at 150 ng /mL). Induces axon outgrowth.
Molecular Mass: ~80 kDa
Endotoxin: <0.01EU/μg purified protein (LAL test; Lonza).
Purity: ≥95% (SDS-PAGE)
Stability: Stable for at least 6 months after receipt when stored at -20 centigrade.
Storage: Short Term Storage at +4 centigrade, Long Term Storage at -20 centigrade.
Concentration: 10 μg vial: 0.1mg/mL after reconstitution.
100 μg vial: 1mg/mL after reconstitution.
Storage Buffer: Contains PBS plus protein stabilizer. No BSA included. The protein stabilizer shows no interference with protein activity.
Reconstitution: Reconstitute with 100 μL sterile distilled water.
Handling: After reconstitution, prepare aliquots and store at -20 centigrade.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.
Gene Name: NTN1 netrin 1 [ Homo sapiens (human) ]
Official Symbol: NTN1
Synonyms: NTN1; netrin 1; NTN1L; epididymis tissue protein Li 131P; netrin 1, mouse, homolog of
Gene ID: 9423
mRNA Refseq: NM_004822
Protein Refseq: NP_004813
MIM: 601614
UniProt ID: O95631

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