| Description : |
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
60.4 kDa |
| AA Sequence : |
MTILPKKKPPPPDADPANEPPPPGP MPPAPRRGGGVGVGGGGTGVGGGDR DRDSGVVGARPRASPPPQGPLPGPP GALHRWALAVPPGAVAGPRPQQASP PPCGGPGGPGGGPGDALGAAAAGVG AAGVVVGVGGAVGVGGCCSGPGHSK RRRQAPGVGAVGGGSPEREEVGAGY NSEDEYEAAAARIEAMDPATVEQQE HWFEKALRDKKGFIIKQMKEDGACL FRAVADQVYGDQDMHEVVRKHCMDY LMKNADYFSNYVTEDFTTYINRKRK NNCHGNHIEMQAMAEMYNRPVEVYQ YSTGTSAVEPINTFHGIHQNEDEPI RVSYHRNIHYNSVVNPNKATIGVGL GLPSFKPGFAEQSLMKNAIKTSEES WIEQQMLEDKKRATDWEATNEAIEE QVARESYLQWLRDQEKQARQVRGPS QPRKASATCSSATAAASSGLEEWTS RSPRQRSSASSPEHPELHAELGMKP PSPGTVLALAKPPSPCAPGTSSQFS AGADRATSPLVSLYPALECRALIQQ MSPSAFGLNDWDDDEILASVLAVSQ QEYLDSMKKNKVHRDPPPDKSTRTR PLEQKLISEEDLAANDILDYKDDDD KV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
