| Cat.No.: | PAWR-538H |
| Product Overview: | Recombinant Human PAWR aa. (Gly48~Gln385) fused with N-terminal His & GST tag was produced in E. coli cells. |
| Description: | The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. |
| Source: | E. coli |
| Species: | Human |
| Tag : | His & GST |
| Form: | Freeze-dried powder |
| Molecular Mass: | 66kDa as determined by SDS-PAGE reducing conditions |
| Protein length: | Gly48~Gln385 |
| Endotoxin: | <1.0EU per 1µg (determined by the LAL method) |
| Purity: | >98% |
| Characteristic: | The isoelectric point is 8.6. |
| Applications: | Positive Control; Immunogen; SDS-PAGE; WB |
| Stability: | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
| Storage: | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
| Concentration: | 200μg/mL |
| Storage buffer: | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300. |
| Reconstitution: | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
| Gene Name: | PAWR pro-apoptotic WT1 regulator [ Homo sapiens (human) ] |
| Official Symbol: | PAWR |
| Synonyms: | PAWR; pro-apoptotic WT1 regulator; PAR4; Par-4; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; WT1-interacting protein; prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein 4; prostate apoptosis response-4; transcriptional repressor PAR4 |
| Gene ID: | 5074 |
| mRNA Refseq: | NM_002583.2 |
| Protein Refseq: | NP_002574.2 |
| UniProt ID: | Q96IZ0 |
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