Recombinant Human PDCD1 protein, Fc-Avi-tagged

Cat.No. : PDCD1-116H
Product Overview : Recombinant human PD1 is expressed from mammalian with a Fc tag and Avi Tag at the C-terminal. It contains Leu25-Gln167.
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Description : Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity.
Source : HEK293
Species : Human
Tag : Fc&Avi
Form : Supplied as 0.22um filtered solution in PBS (pH 7.4).
Molecular Mass : The protein has a predicted MW of 44.7 kDa. Due to glycosylation, the protein migrates to 65-72 KD based on Bis-Tris PAGE result.
Protein length : Leu25-Gln167
Endotoxin : Less than 0.05 EU per ug by the LAL method.
Purity : > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
Gene Name : PDCD1
Official Symbol : PDCD1
Synonyms : hPD-1; PD-1; PD1hPD-1; PDCD1; CD279 antigen; CD279;programmed cell death 1; programmed cell death protein 1; Protein PD-1; SLEB2
Gene ID : 5133
mRNA Refseq : NM_005018.3
Protein Refseq : NP_005009.2
MIM : 600244
UniProt ID : Q15116

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
06/06/2021

    Timely antibody validation, a valuable asset for our laboratory.

    02/12/2021

      Precise protein quantification, fundamental for maintaining data accuracy.

      06/20/2019

        Dependable peptide synthesis, accelerates our peptide-based projects effectively.

        Q&As (14)

        Ask a question
        What are the mechanisms by which PDCD1 modulates the immune response to viral infections? 07/31/2022

        PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.

        What are the mechanisms by which PDCD1 modulates the immune response to viral infections? 11/09/2021

        PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.

        What role does PDCD1 play in the development of immune tolerance? 10/15/2021

        PDCD1 helps develop immune tolerance, preventing overactive immune responses.

        How does PDCD1 influence the balance between immune activation and autoimmunity? 05/23/2021

        PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.

        How does PDCD1 contribute to the exhaustion of T cells in chronic infections and cancer? 08/13/2020

        PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.

        How does PDCD1 influence the balance between immune activation and autoimmunity? 08/05/2020

        PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.

        What is the impact of PDCD1 on the effectiveness of immunotherapy in treating cancers? 12/05/2019

        PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.

        How does PDCD1 contribute to the exhaustion of T cells in chronic infections and cancer? 11/21/2019

        PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.

        How does PDCD1 (PD-1) regulate immune checkpoint pathways in T cells? 04/24/2019

        PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.

        What is the impact of PDCD1 on the effectiveness of immunotherapy in treating cancers? 01/19/2019

        PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.

        What role does PDCD1 play in the development of immune tolerance? 12/08/2018

        PDCD1 helps develop immune tolerance, preventing overactive immune responses.

        How do alterations in PDCD1 expression or signaling affect autoimmune disease progression? 06/24/2018

        Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.

        How does PDCD1 (PD-1) regulate immune checkpoint pathways in T cells? 06/24/2018

        PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.

        How do alterations in PDCD1 expression or signaling affect autoimmune disease progression? 02/06/2018

        Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.

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