Recombinant Human PDE1C Protein, His/GST-tagged

Cat.No. : PDE1C-047H
Product Overview : Recombinant N-terminal His-GST-tagged full length human PDE1C1 protein (1-634) was expressed in insect cells.
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Description : This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta.
Source : Insect cell
Species : Human
Tag : His/GST
Form : Lyophilized
Molecular Mass : 100 kDa
Protein length : 1-634
Endotoxin : <1.0 EU/ μg, determined by the LAL endotoxin assay.
Purity : ≥85% estimated by SDS-PAGE
Stability : ≥ 6 months
Storage : At -80 centigrade.
Storage Buffer : Sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol, 3 mM DTT
SDS-PAGE: Lane 1: MW Markers<br />Lane 2: PDE1C<br />This protein has a calculated molecular weight of 100 kDa. It has an apparent molecular weight of approximately 97 kDa by SDS-PAGE under reducing conditions.
Gene Name : PDE1C phosphodiesterase 1C [ Homo sapiens (human) ]
Official Symbol : PDE1C
Synonyms : PDE1C; phosphodiesterase 1C; Hcam3; DFNA74; hCam-3; cam-PDE 1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; 3',5'-cyclic-AMP phosphodiesterase; 3',5'-cyclic-GMP phosphodiesterase; Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A); phosphodiesterase 1C, calmodulin-dependent 70kDa; EC 3.1.4.35
Gene ID : 5137
mRNA Refseq : NM_005020
Protein Refseq : NP_005011
MIM : 602987
UniProt ID : Q8TAE4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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