| Description : |
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
124.2 kDa |
| AA Sequence : |
MRRDERDAKAMRSLQPPDGAGSPPE SLRNGYVKSCVSPLRQDPPRGFFFH LCRFCNVELRPPPASPQQPRRCSPF CRARLSLGALAAFVLALLLGAEPES WAAGAAWLRTLLSVCSHSLSPLFSI ACAFFFLTCFLTRTKRGPGPGRSCG SWWLLALPACCYLGDFLVWQWWSWP WGDGDAGSAAPHTPPEAAAGRLLLV LSCVGLLLTLAHPLRLRHCVLVLLL ASFVWWVSFTSLGSLPSALRPLLSG LVGGAGCLLALGLDHFFQIREAPLH PRLSSAAEEKVPVIRPRRRSSCVSL GETAASYYGSCKIFRRPSLPCISRE QMILWDWDLKQWYKPHYQNSGGGNG VDLSVLNEARNMVSDLLTDPSLPPQ VISSLRSISSLMGAFSGSCRPKINP LTPFPGFYPCSEIEDPAEKGDRKLN KGLNRNSLPTPQLRRSSGTSGLLPV EQSSRWDRNNGKRPHQEFGISSQGC YLNGPFNSNLLTIPKQRSSSVSLTH HVGLRRAGVLSSLSPVNSSNHGPVS TGSLTNRSPIEFPDTADFLNKPSVI LQRSLGNAPNTPDFYQQLRNSDSNL CNSCGHQMLKYVSTSESDGTDCCSG KSGEEENIFSKESFKLMETQQEEET EKKDSRKLFQEGDKWLTEEAQSEQQ TNIEQEVSLDLILVEEYDSLIEKMS NWNFPIFELVEKMGEKSGRILSQVM YTLFQDTGLLEIFKIPTQQFMNYFR ALENGYRDIPYHNRIHATDVLHAVW YLTTRPVPGLQQIHNGCGTGNETDS DGRINHGRIAYISSKSCSNPDESYG CLSSNIPALELMALYVAAAMHDYDH PGRTNAFLVATNAPQAVLYNDRSVL ENHHAASAWNLYLSRPEYNFLLHLD HVEFKRFRFLVIEAILATDLKKHFD FLAEFNAKANDVNSNGIEWSNENDR LLVCQVCIKLADINGPAKVRDLHLK WTEGIVNEFYEQGDEEANLGLPISP FMDRSSPQLAKLQESFITHIVGPLC NSYDAAGLLPGQWLEAEEDNDTESG DDEDGEELDTEDEEMENNLNPKPPR RKSRRRIFCQLMHHLTENHKIWKEI VEEEEKCKADGNKLQVENSSLPQAD EIQVIEEADEEETRTRPLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
