"PDE4D" Related Products

Recombinant Human PDE4D protein, GST-tagged

Cat.No.: PDE4D-10H
Product Overview: Recombinant Human PDE4D(2–507 aa) fused with GST tag at N-terminal was expressed in Insect cells.
Description: This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
Source: Insect cells
Species: Human
Tag : GST
Form: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% Glycerol and 16 mM Glutathione.
Bio-activity: ≥ 13,600 pmol/min/µg
Molecular Mass: 84 kDa
Purity: > 86%
Unit Definition: One unit is defined as the amount of enzyme that will convert 1 pmole of 3', 5'-cAMP to 5'-AMP per minute at 37 centigrade.
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage: >6 months at -80 centigrade. Avoid freeze/thaw cycles.
Concentration: 0.27 mg/ml
Gene Name: PDE4D phosphodiesterase 4D, cAMP-specific [ Homo sapiens ]
Official Symbol: PDE4D
Synonyms: PDE4D; phosphodiesterase 4D, cAMP-specific; DPDE3, phosphodiesterase 4D, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3); cAMP-specific 3,5-cyclic phosphodiesterase 4D; phosphodiesterase E3 dunce homolog (Drosophila); cAMP-specific phosphodiesterase PDE4D6; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); DPDE3; PDE43; STRK1; HSPDE4D; PDE4DN2; FLJ97311; DKFZp686M11213;
Gene ID: 5144
mRNA Refseq: NM_001197221
Protein Refseq: NP_001184150
MIM: 600129
UniProt ID: Q08499
Chromosome Location: 5q12
Pathway: DARPP-32 events, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Morphine addiction, organism-specific biosystem; Morphine addiction, conserved biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem;
Function: 3,5-cyclic-AMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; cAMP binding; drug binding; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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