Recombinant Human PDE4D protein, GST-tagged

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Recombinant Human PDE4D protein, GST-tagged

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Cat.No. : PDE4D-10H
Product Overview : Recombinant Human PDE4D(2–507 aa) fused with GST tag at N-terminal was expressed in Insect cells.
Description : This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
Source : Insect cells
Species : Human
Tag : GST
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% Glycerol and 16 mM Glutathione.
Bio-activity : ≥ 13,600 pmol/min/µg
Molecular Mass : 84 kDa
Purity : > 86%
Unit Definition : One unit is defined as the amount of enzyme that will convert 1 pmole of 3', 5'-cAMP to 5'-AMP per minute at 37 centigrade.
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : >6 months at -80 centigrade. Avoid freeze/thaw cycles.
Concentration : 0.27 mg/ml
Figure :

Gene Name : PDE4D phosphodiesterase 4D, cAMP-specific [ Homo sapiens ]
Official Symbol : PDE4D
Synonyms : PDE4D; phosphodiesterase 4D, cAMP-specific; DPDE3, phosphodiesterase 4D, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3); cAMP-specific 3,5-cyclic phosphodiesterase 4D; phosphodiesterase E3 dunce homolog (Drosophila); cAMP-specific phosphodiesterase PDE4D6; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); DPDE3; PDE43; STRK1; HSPDE4D; PDE4DN2; FLJ97311; DKFZp686M11213;
Gene ID : 5144
mRNA Refseq : NM_001197221
Protein Refseq : NP_001184150
MIM : 600129
UniProt ID : Q08499
Chromosome Location : 5q12
Pathway : DARPP-32 events, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Morphine addiction, organism-specific biosystem; Morphine addiction, conserved biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem;
Function : 3,5-cyclic-AMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; cAMP binding; drug binding; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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