Recombinant Human PFN1 protein, T7/His-tagged

Cat.No. : PFN1-234H
Product Overview : Recombinant human PFN1 cDNA (2 – 140 aa) fused with T7-His-TEV cleavage site Tag at N-terminal was expressed in E. coli.
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Source : E. coli
Species : Human
Tag : T7/His
Form : 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Sucrose.
AA Sequence : MASMTGGQQMGRGHHHHHHENLYFQ GGEFAGWNAYIDNLMADGTCQDAAI VGYKDSPSVWAAVPGKTFVNITPAE VGVLVGKDRSSFYVNGLTLGGQKCS VIRDSLLQDGEFSMDLRTKSTGGAP TFNVTVTKTDKTLVLLMGKEGVHGG LINKKCYEMASHLRRSQY
Purity : >90% by SDS-PAGE
Storage : Keep at -80 centigrade for long term storage. Product is stable at 4 centigrade for at least 7 days.
Gene Name : PFN1 profilin 1 [ Homo sapiens ]
Official Symbol : PFN1
Synonyms : PFN1; profilin 1; profilin-1; profilin I;
Gene ID : 5216
mRNA Refseq : NM_005022
Protein Refseq : NP_005013
MIM : 176610
UniProt ID : P07737
Chromosome Location : 17p13.2
Pathway : Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; G13 Signaling Pathway, organism-specific biosystem; Hemostasis, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem; Platelet degranulation, organism-specific biosystem; Regulation of Actin Cytoskeleton, organism-specific biosystem;
Function : Rho GTPase binding; actin binding; phosphatidylinositol-4,5-bisphosphate binding; proline-rich region binding; receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is PFN1 protein involved in any other cellular processes apart from cell motility? 11/09/2021

Yes, PFN1 is involved in processes such as endocytosis, cytokinesis, and cell signaling, highlighting its importance in various cellular functions.

Are there ongoing clinical trials targeting PFN1 for cancer treatment? 09/30/2020

Research on targeting PFN1 in cancer therapy is ongoing, and there are clinical trials exploring potential drugs that could inhibit PFN1 activity to impede cancer cell metastasis.

How does PFN1 protein contribute to cancer progression? 05/30/2020

PFN1 has been found to promote cancer cell migration and invasion, suggesting its role in cancer metastasis, making it a potential target for cancer therapy.

Can PFN1 protein be targeted for drug development? 12/22/2019

Yes, researchers are exploring the potential of developing drugs that target PFN1 to modulate its activity, especially in the context of cancer metastasis and neurodegenerative disorders.

How does PFN1 protein affect cell motility and migration? 05/03/2016

PFN1 regulates cell motility and migration by controlling the dynamics of actin filaments, essential components of the cell's cytoskeleton involved in cell movement.

Customer Reviews (3)

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Reviews
08/26/2021

    The manufacturer ensures that the protein is produced with utmost purity and integrity, minimizing the risk of experimental artifacts or compromised results.

    06/22/2021

      Their excellent technical support, commitment to scientific collaboration, and efficient supply chain management greatly contribute to the success and productivity of my research.

      11/09/2020

        One of the key advantages of using PFN1 protein in trials is its high quality.

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