Recombinant Human PFN1 Protein

• Cat.No.: PFN1-884H
• Product Overview: Recombinant Human PFN1 was produced in E. coli.

Specification

• Description: Profilin (15kDa) regulates the G-actin pool by sequestration of actin monomers. Thus profilin controls the growth of actin filaments, and is thus an essential regulator of cellular locomotion and cell shape changes.
  Profilin is negatively regulated by phospholipids (PIP2, InsP3), reversed by phospholipase C.
• Source: E. coli
• Species: Human
• Form: 150mM NaCl, 20mM Hepes pH 7.4, 1mM DTT and 5% sucrose, when reconstituted with 50µl ultrapure water to obtain a 1.0 mg/ml solution.
• Molecular Mass: 15kDa
• Purity: >95% by scanning densitometry from Coomassie G-250 stained SDS-Gels.
• Storage: Profilin is stored at –70 centigrade upon arrival will be stable in performance for at least 6 months from the date of purchase. The solubilized protein is kept on ice and should be stored at -20 centigrade in glycerol or CryoProtect (Cat.#: 6011-01). Avoid repeated freeze / thaw cycles.
• Shipping: At ambient temperature. Upon delivery store at -70 centigrade.

Gene Information

• Gene Name: PFN1 profilin 1 [ Homo sapiens ]
• Official Symbol: PFN1
• Synonyms: PFN1; profilin 1; profilin-1; profilin I
• Gene ID: 5216
• mRNA Refseq: NM_005022
• Protein Refseq: NP_005013
• MIM: 176610
• UniProt ID: P07737

Reviews

08/26/2021

The manufacturer ensures that the protein is produced with utmost purity and integrity, minimizing the risk of experimental artifacts or compromised results.

06/22/2021

Their excellent technical support, commitment to scientific collaboration, and efficient supply chain management greatly contribute to the success and productivity of my research.

11/09/2020

One of the key advantages of using PFN1 protein in trials is its high quality.

Q&As

Is PFN1 protein involved in any other cellular processes apart from cell motility?

Yes, PFN1 is involved in processes such as endocytosis, cytokinesis, and cell signaling, highlighting its importance in various cellular functions.

Are there ongoing clinical trials targeting PFN1 for cancer treatment?

Research on targeting PFN1 in cancer therapy is ongoing, and there are clinical trials exploring potential drugs that could inhibit PFN1 activity to impede cancer cell metastasis.

How does PFN1 protein contribute to cancer progression?

PFN1 has been found to promote cancer cell migration and invasion, suggesting its role in cancer metastasis, making it a potential target for cancer therapy.

Can PFN1 protein be targeted for drug development?

Yes, researchers are exploring the potential of developing drugs that target PFN1 to modulate its activity, especially in the context of cancer metastasis and neurodegenerative disorders.

How does PFN1 protein affect cell motility and migration?

PFN1 regulates cell motility and migration by controlling the dynamics of actin filaments, essential components of the cell's cytoskeleton involved in cell movement.