Active Recombinant Human PNMT protein, GST-tagged

• Cat.No.: PNMT-197H
• Product Overview: Recombinant Human PNMT fused with GST tag at N-terminal was expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Description: Phenylethanolamine N-methyltransferase (PNMT) catalyzes the biosynthesis of adrenaline though methylation of phenylethanolamine. PNMT gene is reported to be involved in various human diseases including early-onset Alzheimer disease, Parkinson's disease, and multiple sclerosis. Expression of PNMT can be stimulated by nicotine.
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 170 nmol/min/mg
• Molecular Mass: 57 kDa
• Purity: >95%
• Applications: Methyltransferase Assay
• Stability: 1 year at -70 centigrade from the date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: PNMT phenylethanolamine N-methyltransferase [ Homo sapiens ]
• Official Symbol: PNMT
• Synonyms: PNMT; phenylethanolamine N-methyltransferase; PENT; phenylethanolamine N-methylase; noradrenaline N-methyltransferase; PNMTase; MGC34570
• Gene ID: 5409
• mRNA Refseq: NM_002686
• Protein Refseq: NP_002677
• MIM: 171190
• UniProt ID: P11086
• Chromosome Location: 17q
• Pathway: Amine-derived hormones, organism-specific biosystem; Biogenic Amine Synthesis, organism-specific biosystem; Catecholamine biosynthesis, organism-specific biosystem; Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline, organism-specific biosystem
• Function: methyltransferase activity; phenylethanolamine N-methyltransferase activity; transferase activity