"PRKACA" Related Products

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Recombinant Human PRKACA Protein, MYC/DDK-tagged

Cat.No. : PRKACA-2952H
Product Overview : Recombinant Human PRKACA protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
Description : This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 39.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : PRKACA protein kinase, cAMP-dependent, catalytic, alpha [ Homo sapiens ]
Official Symbol : PRKACA
Synonyms : PKACA; PPNAD4
Gene ID : 5566
mRNA Refseq : NM_002730
Protein Refseq : NP_002721
MIM : 601639
UniProt ID : P17612

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