Recombinant Human PRNP, His-tagged
Cat.No. : | PRNP-7569H |
Product Overview : | Recombinant human PRNP protein, fused to His-tag at N-terminus, was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Antigen Description : | Prion protein, also known as PRNP, is a ubiquitous membrane glycoprotein whose abnormal self-replicating, misfolded form is widely believed to cause several central nervous system disorders, collectively known as Transmissible Spongiform Encephalopathies (TSE). This protein contains a highly unstable region of five tandem octapeptide repeat. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1M Urea, 10% glycerol |
Molecular Mass : | 25 kDa (229aa) |
Protein length : | 23-230aa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MKKRPKPGGW NTGGSRYPGQ GSPGGNRYPP QGGGGWGQPH GGGWGQPHGG GWGQPHGGGW GQPHGGGWGQ GGGTHSQWNK PSKPKTNMKH MAGAAAAGAV VGGLGGYVLG SAMSRPIIHF GSDYEDRYYR ENMHRYPNQV YYRPMDEYSN QNNFVHDCVN ITIKQHTVTT TTKGENFTET DVKMMERVVE QMCITQYERE SQAYYQRGS |
Purity : | >90% as determined by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/ml |
Gene Name : | PRNP prion protein [ Homo sapiens ] |
Official Symbol : | PRNP |
Synonyms : | PRNP; prion protein; CJD, GSS, prion protein (p27 30) , PRIP; major prion protein; CD230; Creutzfeldt Jakob disease; fatal familial insomnia; Gerstmann Strausler Scheinker syndrome; p27 30; PRP; CD230 antigen; prion-related protein; CJD; GSS; PrP; ASCR; PRIP; PrPc; p27-30; PrP27-30; PrP33-35C; MGC26679; |
Gene ID : | 5621 |
mRNA Refseq : | NM_000311 |
Protein Refseq : | NP_000302 |
MIM : | 176640 |
UniProt ID : | P04156 |
Chromosome Location : | 20p13 |
Pathway : | Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Glypican 1 network, organism-specific biosystem; NCAM signaling for neurite out-growth, organism-specific biosystem; NCAM1 interactions, organism-specific biosystem; Prion diseases, organism-specific biosystem; Prion diseases, conserved biosystem; |
Function : | ATP-dependent protein binding; chaperone binding; copper ion binding; copper ion binding; identical protein binding; metal ion binding; microtubule binding; protein binding; tubulin binding; |
Products Types
◆ Recombinant Protein | ||
PRP-02C | Recombinant Cervid PRNP protein, His-tagged | +Inquiry |
PRNP-3435R | Recombinant Rhesus Macaque PRNP Protein, His (Fc)-Avi-tagged | +Inquiry |
PRNP-7129M | Recombinant Mouse PRNP Protein, His (Fc)-Avi-tagged | +Inquiry |
PRNP-118H | Recombinant Human PRNP Protein, His-tagged | +Inquiry |
PRNP-4367R | Recombinant Rat PRNP Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PRNP-001HCL | Recombinant Human PRNP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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