Recombinant Human PRNP Protein, His-tagged
Cat.No. : | PRNP-118H |
Product Overview : | Recombinant Human PRNP Protein with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | The PRNP gene encodes the major prion protein (PrP, CD230), a widely-expressed glycoprotein expressed at high levels in the central nervous system. While the typical cellular function of PrP is not well defined, it is a putative antioxidant and a metal-binding protein that may be involved in signal transduction. Prion proteins can adopt different conformations; the cellular PrPc prion protein may be converted following translation into the β-sheet-rich scrapie isoform (PrPsc) responsible for several prion diseases, including bovine spongiform encephalopathy and human Creutzfeldt-Jakob disease. Unlike most neurodegenerative diseases, prion diseases are infectious as prions are capable of propagating by conferring an abnormally folded state onto properly folded cellular proteins. In addition, the cellular PrPc has may be involved in β-amyloid peptide oligomerization and synaptic toxicity. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | ~30 kDa |
AA Sequence : | MKKRPKPGGWNTGGSRYPGQGSPGG NRYPPQGGGGWGQPHGGGWGQPHGG GWGQPHGGGWGQPHGGGWGQGGGTH SQWNKPSKPKTNMKHMAGAAAAGAV VGGLGGYMLGSAMSRPIIHFGSDYE DRYYRENMHRYPNQVYYRPMDEYSN QNNFVHDCVNITIKQHTVTTTTKGE NFTETDVKMMERVVEQMCITQYERE SQAYYQRGS |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | PRNP prion protein [ Homo sapiens (human) ] |
Official Symbol : | PRNP |
Synonyms : | PRNP; prion protein; CJD, GSS, prion protein (p27 30) , PRIP; major prion protein; CD230; Creutzfeldt Jakob disease; fatal familial insomnia; Gerstmann Strausler Scheinker syndrome; p27 30; PRP; CD230 antigen; prion-related protein; CJD; GSS; PrP; ASCR; PRIP; PrPc; p27-30; PrP27-30; PrP33-35C; MGC26679; |
Gene ID : | 5621 |
mRNA Refseq : | NM_000311 |
Protein Refseq : | NP_000302 |
MIM : | 176640 |
UniProt ID : | P04156 |
Products Types
◆ Recombinant Protein | ||
PRNP-555C | Recombinant Cynomolgus Monkey PRNP Protein, His (Fc)-Avi-tagged | +Inquiry |
PRNP-742R | Recombinant Rat PRNP Protein (29-231 aa), His-tagged | +Inquiry |
PRNP-4367R | Recombinant Rat PRNP Protein, His (Fc)-Avi-tagged | +Inquiry |
PRP-02C | Recombinant Cervid PRNP protein, His-tagged | +Inquiry |
PRNP-1198H | Recombinant Human PRNP Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PRNP-001HCL | Recombinant Human PRNP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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