Recombinant Human PTPN18 Protein, MYC/DDK-tagged

• Cat.No.: PTPN18-3132H
• Product Overview: Recombinant Human PTPN18 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 50.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) [ Homo sapiens ]
• Official Symbol: PTPN18
• Synonyms: BDP1; PTP-HSCF
• Gene ID: 26469
• mRNA Refseq: NM_014369.3
• Protein Refseq: NP_055184.2
• MIM: 606587
• UniProt ID: Q99952