Recombinant Human PTPN18 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human PTPN18 Protein, Myc/DDK-tagged, C13 and N15-labeled

PTPN18 Related Products

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Cat.No. : PTPN18-6229H
Product Overview : PTPN18 MS Standard C13 and N15-labeled recombinant protein (NP_055184) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 50.3 kDa
AA Sequence : MSRSLDSARS FLERLEARGG REGAVLAGEF SDIQACSAAW KADGVCSTVA GSRPENVRKN RYKDVLPYDQ TRVILSLLQE EGHSDYINGN FIRGVDGSLA YIATQGPLPH TLLDFWRLVW EFGVKVILMA CREIENGRKR CERYWAQEQE PLQTGLFCIT LIKEKWLNED IMLRTLKVTF QKESRSVYQL QYMSWPDRGV PSSPDHMLAM VEEARRLQGS GPEPLCVHCS AGCGRTGVLC TVDYVRQLLL TQMIPPDFSL FDVVLKMRKQ RPAAVQTEEQ YRFLYHTVAQ MFCSTLQNAS PHYQNIKENC APLYDDALFL RTPQALLAIP RPPGGVLRSI SVPGSPGHAM ADTYAVVQKR GAPAGAGSGT QTGTGTGTGA RSAEEAPLYS KVTPRAQRPG AHAEDARGTL PGRVPADQSP AGSGAYEDVA GGAQTGGLGF NLRIGRPKGP RDPPAEWTRV TRTRPLEQKL ISEEDLAAND ILDYKDDDDK V
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : PTPN18 protein tyrosine phosphatase non-receptor type 18 [ Homo sapiens (human) ]
Official Symbol : PTPN18
Synonyms : PTPN18; protein tyrosine phosphatase non-receptor type 18; BDP1; PTP-HSCF; tyrosine-protein phosphatase non-receptor type 18; brain-derived phosphatase; protein tyrosine phosphatase, non-receptor type 18 (brain-derived); EC 3.1.3.48
Gene ID : 26469
mRNA Refseq : NM_014369
Protein Refseq : NP_055184
MIM : 606587
UniProt ID : Q99952

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