| Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
209.7 kDa |
| AA Sequence : |
MAPTWGPGMVSVVGPMGLLVVLLVG GCAAEEPPRFIKEPKDQIGVSGGVA SFVCQATGDPKPRVTWNKKGKKVNS QRFETIEFDESAGAVLRIQPLRTPR DENVYECVAQNSVGEITVHAKLTVL REDQLPSGFPNIDMGPQLKVVERTR TATMLCAASGNPDPEITWFKDFLPV DPSASNGRIKQLRSGALQIESSEET DQGKYECVATNSAGVRYSSPANLYV RVRRVAPRFSILPMSHEIMPGGNVN ITCVAVGSPMPYVKWMQGAEDLTPE DDMPVGRNVLELTDVKDSANYTCVA MSSLGVIEAVAQITVKSLPKAPGTP MVTENTATSITITWDSGNPDPVSYY VIEYKSKSQDGPYQIKEDITTTRYS IGGLSPNSEYEIWVSAVNSIGQGPP SESVVTRTGEQAPASAPRNVQARML SATTMIVQWEEPVEPNGLIRGYRVY YTMEPEHPVGNWQKHNVDDSLLTTV GSLLEDETYTVRVLAFTSVGDGPLS DPIQVKTQQGVPGQPMNLRAEARSE TSITLSWSPPRQESIIKYELLFREG DHGREVGRTFDPTTSYVVEDLKPNT EYAFRLAARSPQGLGAFTPVVRQRT LQSKPSAPPQDVKCVSVRSTAILVS WRPPPPETHNGALVGYSVRYRPLGS EDPEPKEVNGIPPTTTQILLEALEK WTQYRITTVAHTEVGPGPESSPVVV RTDEDVPSAPPRKVEAEALNATAIR VLWRSPAPGRQHGQIRGYQVHYVRM EGAEARGPPRIKDVMLADAQEMVIT NLQPETAYSITVAAYTMKGDGARSK PKVVVTKGAVLGRPTLSVQQTPEGS LLARWEPPAGTAEDQVLGYRLQFGR EDSTPLATLEFPPSEDRYTASGVHK GATYVFRLAARSRGGLGEEAAEVLS IPEDTPRGHPQILEAAGNASAGTVL LRWLPPVPAERNGAIVKYTVAVREA GALGPARETELPAAAEPGAENALTL QGLKPDTAYDLQVRAHTRRGPGPFS PPVRYRTFLRDQVSPKNFKVKMIMK TSVLLSWEFPDNYNSPTPYKIQYNG LTLDVDGRTTKKLITHLKPHTFYNF VLTNRGSSLGGLQQTVTAWTAFNLL NGKPSVAPKPDADGFIMVYLPDGQS PVPVQSYFIVMVPLRKSRGGQFLTP LGSPEDMDLEELIQDISRLQRRSLR HSRQLEVPRPYIAARFSVLPPTFHP GDQKQYGGFDNRGLEPGHRYVLFVL AVLQKSEPTFAASPFSDPFQLDNPD PQPIVDGEEGLIWVIGPVLAVVFII CIVIAILLYKNKPDSKRKDSEPRTK CLLNNADLAPHHPKDPVEMRRINFQ TPGMLSHPPIPIADMAEHTERLKAN DSLKLSQEYESIDPGQQFTWEHSNL EVNKPKNRYANVIAYDHSRVILQPI EGIMGSDYINANYVDGYRRQNAYIA TQGPLPETFGDFWRMVWEQRSATIV MMTRLEEKSRIKCDQYWPNRGTETY GFIQVTLLDTIELATFCVRTFSLHK NGSSEKREVRQFQFTAWPDHGVPEY PTPFLAFLRRVKTCNPPDAGPIVVH CSAGVGRTGCFIVIDAMLERIKPEK TVDVYGHVTLMRSQRNYMVQTEDQY SFIHEALLEAVGCGNTEVPARSLYA YIQKLAQVEPGEHVTGMELEFKRLA NSKAHTSRFISANLPCNKFKNRLVN IMPYESTRVCLQPIRGVEGSDYINA SFIDGYRQQKAYIATQGPLAETTED FWRMLWENNSTIVVMLTKLREMGRE KCHQYWPAERSARYQYFVVDPMAEY NMPQYILREFKVTDARDGQSRTVRQ FQFTDWPEQGVPKSGEGFIDFIGQV HKTKEQFGQDGPISVHCSAGVGRTG VFITLSIVLERMRYEGVVDIFQTVK MLRTQRPAMVQTEDEYQFCYQAALE YLGSFDHYATSGPTRTRRLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
