Description : |
The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
84.4 kDa |
AA Sequence : |
MRRSLAPSQLAKRKPEGRSCDDEDW QPGLVTPRKRKSSSETQIQECFLSP FRKPLSQLTNQPPCLDSSQHEAFIR SILSKPFKVPIPNYQGPLGSRALGL KRAGVRRALHDPLEKDALVLYEPPP LSAHDQLKLDKEKLPVHVVVDPILS KVLRPHQREGVKFLWECVTSRRIPG SHGCIMADEMGLGKTLQCITLMWTL LRQSPECKPEIDKAVVVSPSSLVKN WYNEVGKWLGGRIQPLAIDGGSKDE IDQKLEGFMNQRGARVSSPILIISY ETFRLHVGVLQKGSVGLVICDEGHR LKNSENQTYQALDSLNTSRRVLISG TPIQNDLLEYFSLVHFVNSGILGTA HEFKKHFELPILKGRDAAASEADRQ LGEERLRELTSIVNRCLIRRTSDIL SKYLPVKIEQVVCCRLTPLQTELYK RFLRQAKPAEELLEGKMSVSSLSSI TSLKKLCNHPALIYDKCVEEEDGFV GALDLFPPGYSSKALEPQLSGKMLV LDYILAVTRSRSSDKVVLVSNYTQT LDLFEKLCRARRYLYVRLDGTMSIK KRAKVVERFNSPSSPDFVFMLSSKA GGCGLNLIGANRLVMFDPDWNPAND EQAMARVWRDGQKKTCYIYRLLSAG TIEEKIFQRQSHKKALSSCVVDEEQ DVERHFSLGELKELFILDEASLSDT HDRLHCRRCVNSRQIRPPPDGSDCT SDLAGWNHCTDKWGLRDEVLQAAWD AASTAITFVFHQRSHEEQRGLRTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |