Recombinant Human RB1 protein, T7/His-tagged
Cat.No. : | RB1-173H |
Product Overview : | Recombinant human RB1 pocket domain cDNA (372 -787 aa) protein fused with T7-His-TEV cleavage site Tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Human |
Tag : | T7/His |
Form : | 0.1 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Glycerol. |
AA Sequence : | MASMTGGQQMGRGHHHHHHGNLYFQ GGEHTPVRTVMNTIQQLMMILNSAS DQPSENLISYFNNCTVNPKESILKR VKDIGYIFKEKFAKAVGQGCVEIGS QRYKLGVRLYYRVMESMLKSEEERL SIQNFSKLLNDNIFHMSLLACALEV VMATYSRSTSQNLDSGTDLSFPWIL NVLNLKAFDFYKVIESFIKAEGNLT REMIKHLERCEHRIMESLAWLSDSP LFDLIKQSKDREGPTDHLESACPLN LPLQNNHTAADMYLSPVRSPKKKGS TTRVNSTANAETQATSAFQTQKPLK STSLSLFYKKVYRLAYLRLNTLCER LLSEHPELEHIIWTLFQHTLQNEYE LMRDRHLDQIMMCSMYGICKVKNID LKFKIIVTAYKDLPHAVQETFKRVL IKEEEYDSIIVFYNSVFMQRLKTNI LQYASTRPPTLSPIPHIPR |
Purity : | >90% by SDS-PAGE. |
Storage : | Keep at -20°C for long term storage. Product is stable at 4 °C for at least 7 days. |
Gene Name : | RB1 retinoblastoma 1 [ Homo sapiens ] |
Official Symbol : | RB1 |
Synonyms : | RB1; retinoblastoma 1; OSRC, osteosarcoma; retinoblastoma-associated protein; RB; retinoblastoma suspectibility protein; pRb; OSRC; pp110; p105-Rb; |
Gene ID : | 5925 |
mRNA Refseq : | NM_000321 |
Protein Refseq : | NP_000312 |
MIM : | 614041 |
UniProt ID : | P06400 |
Chromosome Location : | 13q14.2 |
Pathway : | Adipogenesis, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; |
Function : | DNA binding; RNA polymerase II activating transcription factor binding; androgen receptor binding; core promoter binding; kinase activity; kinase binding; molecular_function; phosphoprotein binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription factor binding; ubiquitin protein ligase binding; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMutations in RB1 lead to retinoblastoma and increase the risk of other cancers, disrupting normal cell cycle control.
RB1 interacts with transcription factors to regulate gene expression, impacting various cellular processes.
RB1 plays a crucial role in the DNA damage response, facilitating repair and maintaining genomic stability.
RB1 controls the G1 to S phase transition in the cell cycle, preventing unregulated cell division.
Changes in RB1 function affect stem cell differentiation and tissue regeneration, influencing tissue maintenance and repair.
RB1 influences cellular senescence and apoptosis, playing a role in aging and cell turnover.
As a tumor suppressor, RB1 prevents excessive cell proliferation and contributes to cancer prevention.
Customer Reviews (3)
Write a reviewEfficient protein purification, delivers consistent yield and purity.
Expertise in protein engineering, a trusted resource for research.
Reliable protein crystallization services, exceptional results achieved.
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