Recombinant Human ROR1

• Cat.No.: ROR1-30958TH
• Product Overview: Recombinant fragment of Human ROR1 with a N terminal proprietary tag. Predicted molecular weight 36.63 kDa.

Specification

• Description: The protein encoded by this gene is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: ANCIRIGIPMADPINKNHKCYNSTG VDYRGTVSVTKSGRQCQPWNSQYPH THTFTALRFPELNGGHSYCRNPGNQ KEAPWCFTLDENFKSDLCDIPACGK
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.Contains 1 FZ (frizzled) domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 kringle domain.Contains 1 protein kinase domain.
• Tag: Non

Gene Information

• Gene Name: ROR1 receptor tyrosine kinase-like orphan receptor 1 [ Homo sapiens ]
• Official Symbol: ROR1
• Synonyms: ROR1; receptor tyrosine kinase-like orphan receptor 1; NTRKR1; tyrosine-protein kinase transmembrane receptor ROR1
• Gene ID: 4919
• mRNA Refseq: NM_001083592
• Protein Refseq: NP_001077061
• MIM: 602336
• Uniprot ID: Q01973
• Chromosome Location: 1p32-p31
• Pathway: Nuclear Receptors, organism-specific biosystem
• Function: ATP binding; Wnt-protein binding; kinase activity; nucleotide binding; receptor activity

Reviews

10/18/2022

Customer service promptly feedback my requests, technical staff timely solve the problems that arise.

08/13/2022

Excellent after-sales service, solving many experimental problems.

04/12/2021

Fast and timely shipment helped me to get satisfactory experimental results in short time.

Q&As

What is the expression level of ROR1 in normal tissues.

ROR1 is barely expressed in normal, differentiated and mature tissues, but is highly expressed in tumor tissues.

What are the effects of inhibiting ROR1 expression?

Inhibit the expression of ROR1 can reduce the proliferation and migration ability of tumor cells.

What biological processes is ROR1 involved in?

ROR1 is involved in the regulation of cell metabolism, proliferation, apoptosis, and differentiation.

What diseases is ROR1 involved in?

ROR1 is involved in the study of breast, lung and ovarian cancers.