"ROR1" Related Products

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Recombinant Human ROR1 protein, Fc & Avi-tagged, Biotinylated

Cat.No.: ROR1-1811H
Product Overview: Biotinylated Human ROR1, Fc Tag is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Glu 403 (Accession # AAA60275.1). Biotinylation of this product is performed using Avitag technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin. The biotin to protein ratio is 0.5-1 as determined by the HABA assay.
Description: Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.
Source: HEK293
Species: Human
Tag : Fc & Avi
Form: Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5, 10% trehalose.
Molecular Mass: This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 70.4 kDa. As a result of Glycosylation, the protein migrates as 79-104 kDa under reducing (R) condition, and 158-208 kDa under non-reducing (NR) condition (SDS-PAGE).
Protein length: AA Gln 30 - Glu 403
Endotoxin: Less than 1.0 EU per μg by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. No activity loss is observed after storage at: 4-8°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Gene Name: ROR1 receptor tyrosine kinase like orphan receptor 1 [ Homo sapiens (human) ]
Official Symbol: ROR1
Synonyms: NTRKR1; dJ537F10.1; neurotrophic tyrosine kinase; receptor-related 1
Gene ID: 4919
mRNA Refseq: NM_001083592.1
Protein Refseq: NP_001077061.1
UniProt ID: Q01973

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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