Recombinant Human ROR1 Protein, His-tagged

Cat.No. : ROR1-512H
Product Overview : Recombinant Human ROR1(Gly540~Gly795) fused with His tag at N-terminal was expressed in E. coli.
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Description : This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 32.8kDa
Protein length : Gly540~Gly795
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 98%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others.
SDS-PAGE:
Gene Name : ROR1 receptor tyrosine kinase-like orphan receptor 1 [ Homo sapiens ]
Official Symbol : ROR1
Synonyms : ROR1; receptor tyrosine kinase-like orphan receptor 1; NTRKR1; tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase receptor-related 1; neurotrophic tyrosine kinase, receptor-related 1; dJ537F10.1; MGC99659;
Gene ID : 4919
mRNA Refseq : NM_001083592
Protein Refseq : NP_001077061
MIM : 602336
UniProt ID : Q01973

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (4)

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What is the expression level of ROR1 in normal tissues. 11/28/2022

ROR1 is barely expressed in normal, differentiated and mature tissues, but is highly expressed in tumor tissues.

What are the effects of inhibiting ROR1 expression? 07/14/2022

Inhibit the expression of ROR1 can reduce the proliferation and migration ability of tumor cells.

What biological processes is ROR1 involved in? 12/26/2021

ROR1 is involved in the regulation of cell metabolism, proliferation, apoptosis, and differentiation.

What diseases is ROR1 involved in? 03/01/2021

ROR1 is involved in the study of breast, lung and ovarian cancers.

Customer Reviews (3)

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10/18/2022

    Customer service promptly feedback my requests, technical staff timely solve the problems that arise.

    08/13/2022

      Excellent after-sales service, solving many experimental problems.

      04/12/2021

        Fast and timely shipment helped me to get satisfactory experimental results in short time.

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