Recombinant Human RPS6KA6, GST-tagged, Active

• Cat.No.: RPS6KA6-427H
• Product Overview: Recombinant full-length human RPS6KA6 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=112kDa.

Specification

• Cat. No.: RPS6KA6-427H
• Description: RSK4 is a member of the 90-kDa ribosomal S6 kinase family which are important components of growth factor mediated stimulation of cellular proliferation, survival and differentiation. RSK4 is activated via coordinated phosphorylation by ERK and 3-phosphoinositide-dependent protein kinase-1 (PDK1). RSK4 is often associated with contiguous gene syndromes consisting of X-linked deafness type 3 (DFN3), mental retardation (MRX) and choroideremia (CHM). RSK4 is most abundantly expressed in the brain and kidney.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• nullValue_other: Long-term potentiation; MAPK signaling pathway; Neurotrophin signaling pathway; Progesterone-mediated oocyte maturation; mTOR signaling pathway; Signalling by NGF

Gene Information

• Gene Name: RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 [ Homo sapiens ]
• Synonyms: RPS6KA6; ribosomal protein S6 kinase, 90kDa, polypeptide 6; RSK4; PP90RSK4; S6K-alpha 6; ribosomal S6 kinase 4; EC 2.7.11.1
• Gene ID: 27330
• mRNA Refseq: NM_014496
• Protein Refseq: NP_055311
• MIM: 300303
• UniProt ID: Q9UK32
• Chromosome Location: Xq21
• Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; transferase activity; protein serine/threonine kinase activity