Recombinant Human SETD7 Protein, His-tagged SETD7-22H

Recombinant Human SETD7 Protein, His-tagged

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Recombinant Human SETD7 Protein, His-tagged

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Cat.No. : SETD7-22H
Product Overview : Recombinant human SETD7(1-366) protein with a N-terminal His-tag was expressed in E. coli.
Description : Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function. Lysine residues can be mono-, di-, or tri-methylated, and unlike most SET proteins, SET7/9 is exclusively a mono-methylase. SET7/9 methylates histone H3, tumor suppressor p53, and transcription factor TAF10. Recently, SET7/9 was shown to catalyze methylation of p53 in response to DNA damage thereby activating p53 for subsequent acetylation. SET7/9 is able to modulate p53 activity in a human cancer cell line, implying that it may play a significant role in human tumorigenesis.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 43.3 kDa
Protein length : 1-366
Purity : ≥95% estimated by SDS-PAGE
Stability : ≥ 6 months
Storage : Store it at -80 centigrade
Storage Buffer : 50 mM HEPES, pH 7.2, 100 mM sodium chloride, and 20% glycerol
Figure :

SDS-PAGE Analysis of SETD7 :

Lane 1: MW Markers; Lane 2: SET7/9 (1 μg); Lane 3: SET7/9 (2 μg); Lane 4: SET7/9 (5 μg). Representative gel image shown; actual purity may vary between each batch but protein will be ≥95% pure.

Gene Name : SETD7 SET domain containing 7, histone lysine methyltransferase [ Homo sapiens (human) ]
Official Symbol : SETD7
Synonyms : SETD7; SET domain containing 7, histone lysine methyltransferase; KMT7; SET7; SET9; SET7/9; histone-lysine N-methyltransferase SETD7; H3-K4-HMTase SETD7; SET domain containing 7, lysine methyltransferase; SET domain containing lysine methyltransferase 7; SET domain-containing protein 7; histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; lysine N-methyltransferase 7
Gene ID : 80854
mRNA Refseq : NM_001306199
Protein Refseq : NP_001293128
MIM : 606594
UniProt ID : Q8WTS6

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