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Recombinant Human SIRT5 Protein (Arg2-Ser310), FLAG-tagged

Cat.: SIRT5-677H
Cat.No.: SIRT5-677H
Product Overview: Recombinant Human SIRT5 Protein (NP_036373.1) (Arg2-Ser310) was produced by E. coli expression system. This protein was expressed with a FLAG tag at the N-terminus.
Description: The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellular homeostasis, in a context- and cell-type specific manner, as has been observed previously for other sirtuin family members. SIRT5 regulates protein substrates involved in glycolysis, the TCA cycle, fatty acid oxidation, electron transport chain, ketone body formation, nitrogenous waste management, and ROS detoxification, among other processes. SIRT5 plays pivotal roles in cardiac physiology and stress responses and is involved in the regulation of numerous aspects of myocardial energy metabolism. SIRT5 is implicated in neoplasia, as both a tumor promoter and suppressor in a context-specific manner, and may serve a protective function in the setting of neurodegenerative disorders. The SIRT5 downregulation is associated with increased succinylation and activity of ACOX1 and oxidative DNA damage response in hepatocellular carcinoma (HCC).
Source: E. coli
Species: Human
Tag : FLAG
Predicted N Terminal: Met
Form: Lyophilized from sterile PBS, 1 mM DTT, pH 8.2. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass: The recombinant human SIRT5 consists of 318 amino acids and predicts a molecular mass of 34.9 kDa.
Protein length: Arg2-Ser310
Purity: > 90 % as determined by SDS-PAGE.
Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name: SIRT5 sirtuin 5 [ Homo sapiens ]
Official Symbol: SIRT5
Synonyms: SIRT5; sirtuin 5; sir2-like 5; sirtuin type 5; SIR2L5; FLJ36950;
Gene ID: 23408
mRNA Refseq: NM_001193267
Protein Refseq: NP_001180196
MIM: 604483
UniProt ID: Q9NXA8

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