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Active Recombinant Human SLAMF7 protein, Avi-His-tagged, Biotinylated

Cat.No. : SLAMF7-187H
Product Overview : Biotinylated Recombinant Human SLAMF7 protein(Ser 23 - Met 226), fused with Avi and His tag, was expressed in HEK293.
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Source : HEK293
Species : Human
Tag : Avi-His
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Bio-activity : Immobilized Anti-SLAMF7/CS1 Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind Biotinylated Human SLAMF7, Avitag,His Tag with a linear range of 0.2-2 ng/mL. Immobilized Humanized Anti-Human CS1 MAb at 1 μg/mL (100 μL/well) can bind Biotinylated Human SLAMF7, Avitag,His Tag with a linear range of 0.6-5 ng/mL.
Molecular Mass : This protein carries an Avi tag (Avitag) at the C-terminus, followed by a polyhistidine tagThe protein has a calculated MW of 25.6 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein Length : Ser 23 - Met 226
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE. >90% as determined by SEC-HPLC.
Storage : For long term, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after at:
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : SLAMF7 SLAM family member 7 [ Homo sapiens ]
Official Symbol : SLAMF7
Synonyms : SLAMF7; SLAM family member 7; 19A; CD319; CRACC; CS1; protein 19A; CD2 subset 1; 19A24 protein; membrane protein FOAP-12; CD2-like receptor activating cytotoxic cells; CD2-like receptor-activating cytotoxic cells; novel LY9 (lymphocyte antigen 9) like protein;
Gene ID : 57823
mRNA Refseq : NM_021181
Protein Refseq : NP_067004
MIM : 606625
UniProt ID : Q9NQ25

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the mechanism by which SLAMF7 protein regulates immune responses? 10/13/2022

SLAMF7 protein is involved in regulating immune cell activation, proliferation, and transmission of background signals by binding to activating ligands, such as CD319, thereby influencing the immune response.

What is the potential of combining SLAMF7 protein with immunotherapy? 05/02/2022

By combining with immunotherapy, such as anti-PD-1 antibodies, the immune response can be further enhanced and the anti-tumor effect can be improved. The study of SLAMF7 protein provides a new direction for the development of combinatorial therapeutic strategies.

In which tissues or cells is SLAMF7 protein expressed? 12/13/2021

This protein is mainly expressed in the immune system, including immune cells such as plasma cells, NK cells, and activated T cells.

Does the SLAMF7 protein have a similar role in other types of cancer? 11/14/2020

The role of SLAMF7 protein in other types of cancer is unclear, and further research is needed to determine its potential role in other cancers.

Does SLAMF7 protein have potential in the treatment of multiple myeloma? 05/20/2020

Yes, the SLAMF7 protein has been shown to be a potential therapeutic target. A monoclonal antibody drug targeting SLAMF7 protein (Elotuzumab) has been developed for the treatment of multiple myeloma.

What is the function of SLAMF7 protein in multiple myeloma? 12/11/2019

SLAMF7 protein interacts with NK cells in multiple myeloma and plays a role in inhibiting and controlling tumor growth by activating the anti-tumor activity of NK cells.

Customer Reviews (3)

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07/28/2023

    It has a high solubility and can be easily prepared at the desired concentration.

    07/26/2021

      It was found to be well active and could effectively perform the required biological activity experiments.

      04/15/2020

        It was observed that SLAMF7 had good crystallinity, which was conducive to crystallography research.

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