| Description : |
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. |
| Source : |
Insect cells |
| Species : |
Human |
| Tag : |
His-FLAG |
| Molecular Mass : |
181 kDa |
| AA Sequence : |
MSTPTDPGAMPHPGPSPGPGPSPGP ILGPSPGPGPSPGSVHSMMGPSPGP PSVSHPMPTMGSTDFPQEGMHQMHK PIDGIHDKGIVEDIHCGSMKGTGMR PPHPGMGPPQSPMDQHSQGYMSPHP SPLGAPEHVSSPMSGGGPTPPQMPP SQPGALIPGDPQAMSQPNRGPSPFS PVQLHQLRAQILAYKMLARGQPLPE TLQLAVQGKRTLPGLQQQQQQQQQQ QQQQQQQQQQQQQPQQQPPQPQTQQ QQQPALVNYNRPSGPGPELSGPSTP QKLPVPAPGGRPSPAPPAAAQPPAA AVPGPSVPQPAPGQPSPVLQLQQKQ SRISPIQKPQGLDPVEILQEREYRL QARIAHRIQELENLPGSLPPDLRTK ATVELKALRLLNFQRQLRQEVVACM RRDTTLETALNSKAYKRSKRQTLRE ARMTEKLEKQQKIEQERKRRQKHQE YLNSILQHAKDFKEYHRSVAGKIQK LSKAVATWHANTEREQKKETERIEK ERMRRLMAEDEEGYRKLIDQKKDRR LAYLLQQTDEYVANLTNLVWEHKQA QAAKEKKKRRRRKKKAEENAEGGES ALGPDGEPIDESSQMSDLPVKVTHT ETGKVLFGPEAPKASQLDAWLEMNP GYEVAPRSDSEESDSDYEEEDEEEE SSRQETEEKILLDPNSEEVSEKDAK QIIETAKQDVDDEYSMQYSARGSQS YYTVAHAISERVEKQSALLINGTLK HYQLQGLEWMVSLYNNNLNGILADE MGLGKTIQTIALITYLMEHKRLNGP YLIIVPLSTLSNWTYEFDKWAPSVV KISYKGTPAMRRSLVPQLRSGKFNV LLTTYEYIIKDKHILAKIRWKYMIV DEGHRMKNHHCKLTQVLNTHYVAPR RILLTGTPLQNKLPELWALLNFLLP TIFKSCSTFEQWFNAPFAMTGERVD LNEEETILIIRRLHKVLRPFLLRRL KKEVESQLPEKVEYVIKCDMSALQK ILYRHMQAKGILLTDGSEKDKKGKG GAKTLMNTIMQLRKICNHPYMFQHI EESFAEHLGYSNGVINGAELYRASG KFELLDRILPKLRATNHRVLLFCQM TSLMTIMEDYFAFRNFLYLRLDGTT KSEDRAALLKKFNEPGSQYFIFLLS TRAGGLGLNLQAADTVVIFDSDWNP HQDLQAQDRAHRIGQQNEVRVLRLC TVNSVEEKILAAAKYKLNVDQKVIQ AGMFDQKSSSHERRAFLQAILEHEE ENEEEDEVPDDETLNQMIARREEEF DLFMRMDMDRRREDARNPKRKPRLM EEDELPSWIIKDDAEVERLTCEEEE EKIFGRGSRQRRDVDYSDALTEKQW LRAIEDGNLEEMEEEVRLKKRKRRR NVDKDPAKEDVEKAKKRRGRPPAEK LSPNPPKLTKQMNAIIDTVINYKDS SGRQLSEVFIQLPSRKELPEYYELI RKPVDFKKIKERIRNHKYRSLGDLE KDVMLLCHNAQTFNLEGSQIYEDSI VLQSVFKSARQKIAKEEESEDESNE EEEEEDEEESESEAKSVKVKIKLNK KDDKGRDKGKGKKRPNRGKAKPVVS DFDSDEEQDEREQSEGSGTDDEHHH HHHDYKDDDDK |
| Purity : |
> 50% by SDS-PAGE |
| Storage : |
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Concentration : |
0.05 mg/mL by BCA |
| Storage Buffer : |
Sterile 25mM Hepes, 0.1M EDTA, 10% glycerol, 350mM NaCl, pH7.6 |
