Recombinant Human TGIF1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human TGIF1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : TGIF1-4324H
Product Overview : TGIF1 MS Standard C13 and N15-labeled recombinant protein (NP_775300) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 29.7 kDa
AA Sequence : MKGKKGIVAA SGSETEDEDS MDIPLDLSSS AGSGKRRRRG NLPKESVQIL RDWLYEHRYN AYPSEQEKAL LSQQTHLSTL QVCNWFINAR RRLLPDMLRK DGKDPNQFTI SRRGAKISET SSVESVMGIK NFMPALEETP FHSCTAGPNP TLGRPLSPKP SSPGSVLARP SVICHTTVTA LKDVPFSLCQ SVGVGQNTDI QQIAAKNFTD TSLMYPEDTC KSGPSTNTQS GLFNTPPPTP PDLNQDFSGF QLLVDVALKR AAEMELQAKL TATRTRPLEQ KLISEEDLAA NDILDYKDDD DKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : TGIF1 TGFB-induced factor homeobox 1 [ Homo sapiens (human) ]
Official Symbol : TGIF1
Synonyms : TGIF1; TGFB-induced factor homeobox 1; HPE4, TGFB induced factor (TALE family homeobox), TGIF; homeobox protein TGIF1; homeobox protein TGIF; 5-TG-3 interacting factor; 5-TG-3-interacting factor 1; TALE homeobox TG-interacting factor; transforming growth factor-beta-induced factor; HPE4; TGIF; MGC5066; MGC39747;
Gene ID : 7050
mRNA Refseq : NM_173208
Protein Refseq : NP_775300
MIM : 602630
UniProt ID : Q15583

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