Recombinant Human TNFR2 Protein, mFc-tagged
Cat.No. : | TNFRSF1B-333H |
Product Overview : | Human TNFR2 Protein is expressed from mammalian with mFc at the C-terminal. It contains Leu23-Asp257. |
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Description : | Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. |
Source : | HEK293 |
Species : | Human |
Tag : | mFc |
Form : | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 5 % trehalose is added as protectant before lyophilization. |
Molecular Mass : | The protein has a predicted MW of 51.5 KDa. Due to glycosylation, the protein migrates to 65- 75KDa based on Bis-Tris PAGE result. |
Protein length : | Leu23-Asp257 |
Endotoxin : | Less than 0.01EU per ug by the LAL method. |
Purity : | > 95% as determined by SDS-PAGE; > 95% as determined by HPLC |
Storage : | The product should be stored at -70°C or -20°C. |
Gene Name : | TNFRSF1B |
Official Symbol : | TNFRSF1B |
Synonyms : | CD120b antigen; CD120b; Etanercept; p75 TNF receptor; p75TBPII; p75TNFR; soluble TNFR1B variant 1; TNF RII; TNFBRp80 TNF-alpha receptor; TNF-R2; TNFR2TNFR1B; TNF-R75; TNFR80; TNFRII; TNF-RII; TNF-R-II; TNFR-II; TNFRSF1B; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor type II; TNFR2;TNF R2 |
Gene ID : | 7133 |
mRNA Refseq : | NM_001066.3 |
Protein Refseq : | NP_001057.1 |
MIM : | 191191 |
UniProt ID : | P20333 |
Products Types
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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