Recombinant Human TNFR2 Protein, mFc-tagged

• Cat.No.: TNFRSF1B-333H
• Product Overview: Human TNFR2 Protein is expressed from mammalian with mFc at the C-terminal. It contains Leu23-Asp257.

Specification

• Description: Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
• Source: HEK293
• Species: Human
• Tag: mFc
• Form: Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 5 % trehalose is added as protectant before lyophilization.
• Molecular Mass: The protein has a predicted MW of 51.5 KDa. Due to glycosylation, the protein migrates to 65- 75KDa based on Bis-Tris PAGE result.
• Protein length: Leu23-Asp257
• Endotoxin: Less than 0.01EU per ug by the LAL method.
• Purity: > 95% as determined by SDS-PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C or -20°C.

Gene Information

• Gene Name: TNFRSF1B
• Official Symbol: TNFRSF1B
• Synonyms: CD120b antigen; CD120b; Etanercept; p75 TNF receptor; p75TBPII; p75TNFR; soluble TNFR1B variant 1; TNF RII; TNFBRp80 TNF-alpha receptor; TNF-R2; TNFR2TNFR1B; TNF-R75; TNFR80; TNFRII; TNF-RII; TNF-R-II; TNFR-II; TNFRSF1B; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor type II; TNFR2;TNF R2
• Gene ID: 7133
• mRNA Refseq: NM_001066.3
• Protein Refseq: NP_001057.1
• MIM: 191191
• UniProt ID: P20333