Recombinant Human TNFRSF11A protein, Mouse IgG2a Fc-tagged, low endotoxin TNFRSF11A-392H

September 27-30, 2022

Boston Convention and Exhibition Center

Booth #336

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Recombinant Human TNFRSF11A protein, Mouse IgG2a Fc-tagged, low endotoxin

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Cat.No. : TNFRSF11A-392H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human TNFRSF11A protein (Ile30-Pro212)(low endotoxin), fused to Mouse IgG2a Fc tag at C-terminus, was expressed in human 293 cells (HEK293).
Description : RANK/TNFRSF11A is a member of the tumor necrosis factor receptor family. RANK/TNFRSF11A shares significant amino acid homology with other members of the TNF R family in its extracellular four cysteine-rich repeats. Functional genomics in mice showed that RANKL (TNFSF11), a member of the TNF ligand superfamily, and RANK (TNFRSF11a), the cognate TNFR family receptor for RANKL, were essential for osteoclastogenesis in vivo. A functional interaction between RANKL, expressed by bone stromal cells of the osteoblast lineage, and RANK, expressed by osteoclast precursors of hematopoietic myeloid lineage, is necessary for osteoclast differentiation, survival, and activation.
Source : HEK293
Species : Human
Tag : Mouse IgG2a Fc
Form : Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 47.2 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : 183
Endotoxin : Less than 0.1 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
SDS-PAGE of TNFRSF11A-392H :

Human RANK, Mouse IgG2a Fc Tag, low endotoxin on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA of TNFRSF11A-392H :

Immobilized Human TNFSF11, His Tag at 2 μg/mL (100 μL/well) can bind Human RANK, Mouse IgG2a Fc Tag, low endotoxin with a linear range of 0.4-13 ng/mL (QC tested).

Bioactivity-SPR of TNFRSF11A-392H :

Captured Human RANK, Mouse IgG2a Fc Tag, low endotoxin on CM5 chip via Anti-Mouse antibodies surface can bind Human TNFSF11, His Tag with an affinity constant of 0.309 nM as determined in a SPR assay (Routinely tested).

Gene Name : TNFRSF11A
Official Symbol : TNFRSF11A
Synonyms : TNFRSF11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator; tumor necrosis factor receptor superfamily, member 11a, activator of NFKB; tumor necrosis factor receptor superfamily member 11A; CD265; RANK; receptor activator of NF-KB; osteoclast differentiation factor receptor; receptor activator of nuclear factor-kappa B; loss of heterozygosity, 18, chromosomal region 1; FEO; OFE; ODFR; OSTS; PDB2; OPTB7; TRANCER; LOH18CR1
Gene ID : 8792
mRNA Refseq : NM_003839
Protein Refseq : NP_003830
MIM : 603499
UniProt ID : Q9Y6Q6
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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