Recombinant Human TNFRSF21

• Cat.No.: TNFRSF21-1604H

Specification

• Cat. No.: TNFRSF21-1604H
• Description: Death receptor-6 (DR6), a member of the death domain-containing TNFR superfamily, is highly expressed in lymphoid tissues and regulated upon lymphocyte activation. Targeted disruption of DR6 results in enhanced CD4(+) T cell proliferation and T helper 2 differentiation in vitro. DR6 contains an extracellular region and an intracellular region; the intracellular region harbors a death domain that is critical for transduction of apoptotic signals. DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK.
• Molecular Weight: The predicted molecular weight of Recombinant Human DR6 is Mr 60.3 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 65-75 kDa.
• Source: Sf 21 Insect Cells.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: TNFRSF21 tumor necrosis factor receptor superfamily, member 21 [ Homo sapiens ]
• Synonyms: TNFRSF21; tumor necrosis factor receptor superfamily, member 21; DR6; BM-018; MGC31965; death receptor 6; death receptor 6; TNFR-related death receptor 6; OTTHUMP00000016561; OTTHUMP00000039915
• Gene ID: 27242
• mRNA Refseq: NM_014452
• Protein Refseq: NP_055267
• MIM: 605732
• UniProt ID: O75509
• Chromosome Location: p21
• Pathway: Cytokine-cytokine receptor interaction
• Function: protein binding; receptor activity