Active Recombinant Human TNFRSF9 Protein, Fc & Avi-tagged, Biotinylated
Cat.No. : | TNFRSF9-346H |
Product Overview : | Recombinant Human TNFRSF9 Protein, Fc & Avi-tagged, Biotinylated is expressed from human 293 cells (HEK293). It contains AA Leu 24 - Gln 186 (Accession # NP_001552.2). Predicted N-terminus: Leu 24. This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag. The protein has a calculated MW of 45.7 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
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Source : | HEK293 |
Species : | Human |
Tag : | Fc & Avi |
Form : | Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization. |
Bio-activity : | Human TNFSF9 Ligand, Fc-tag at 2 μg/mL (100 μL/well) can bind Recombinant Human TNFRSF9 protein, Fc & Avi-tagged, Biotinylated with a linear range of 2-19 ng/mL (QC tested). |
Molecular Mass : | 45.7 kDa |
Protein length : | Leu 24 - Gln 186 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Notes : | Please avoid repeated freeze-thaw cycles. |
Stability : | No activity loss is observed after storage at: 4-8 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | TNFRSF9 tumor necrosis factor receptor superfamily, member 9 [ Homo sapiens ] |
Official Symbol : | TNFRSF9 |
Synonyms : | TNFRSF9; ILA; 4 1BB; CD137; CD137 antigen; 4-1BB; CDw137; MGC2172; FLJ43501; |
Gene ID : | 3604 |
mRNA Refseq : | NM_001561 |
Protein Refseq : | NP_001552 |
MIM : | 602250 |
UniProt ID : | Q07011 |
Products Types
◆ Recombinant Protein | ||
TNFRSF9-076H | Recombinant Human TNFRSF9 Protein, C-His-tagged | +Inquiry |
TNFRSF9-329H | Recombinant Human TNFRSF9 Protein (Met1-Gln186), His-tagged, Biotinylated | +Inquiry |
TNFRSF9-1052C | Recombinant Canine TNFRSF9 protein(Met1-Ser185), hFc-tagged | +Inquiry |
TNFRSF9-844M | Recombinant Mouse TNFRSF9 Protein (Met1-Leu211), RlgG Fc-tagged | +Inquiry |
TNFRSF9-1233C | Acitve Recombinant Cynomolgus/Rhesus TNFRSF9 protein(Met1-Gln186), His-tagged | +Inquiry |
◆ Lysates | ||
TNFRSF9-2162HCL | Recombinant Human TNFRSF9 cell lysate | +Inquiry |
TNFRSF9-1792MCL | Recombinant Mouse TNFRSF9 cell lysate | +Inquiry |
TNFRSF9-928CCL | Recombinant Canine TNFRSF9 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionStudies have found that abnormal expression levels of TNFRSF9 may be associated with certain tumors, autoimmune diseases, and inflammatory diseases.
It has a variety of associations with other proteins and cytokines. For example, it may interact with the NF-kB signaling pathway to regulate the inflammatory response, and it may also interact with apoptosis-related proteins to regulate the apoptosis process.
TNFRSF9 mainly plays an important role in the immune system, as an activating signaling molecule, it is able to stimulate the activation, proliferation and survival of T cells and NK cells.
Inhibitors or activators targeting TNFRSF9 may have potential applications for the treatment of certain tumors, autoimmune diseases, and inflammatory diseases.
The extracellular domain of TNFRSF9 can bind to its ligand, such as 4-1BBL, to initiate signal transduction, which in turn activates downstream signaling pathways.
TNFRSF9 has some potential in tumor immunotherapy. Several antibody drugs have been developed to use the stimulating effects of TNFRSF9 to enhance the activity of immune cells to fight tumors.
Customer Reviews (3)
Write a reviewGood heat resistance, long time treatment at high temperature, still has activity.
The results obtained by SDS-PAGE or Western blot analysis were good.
The purity is good, and the experimental results obtained are accurate.
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