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Active Recombinant Human TNFSF10 Protein

Cat.No. : TNFSF10-635H
Product Overview : Recombinant Human TNFSF10 Protein extracellular domain 95-281aa (signal peptide removed), fused with no tag, was expressed in E.coli.
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Description : Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 / Apo-2L / CD253 functions as a ligand that induces the process of cell death called apoptosis. TNFSF10 / TRAIL shows homology to other members of the tumor necrosis factor superfamily. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. TNFSF10 binds to several members of TNF receptor superfamily including TNFRSF10A / TRAILR1, TNFRSF10B / TRAILR2, TNFRSF10C / TRAILR3, TNFRSF10D / TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of TNFSF10 / TRAIL may be modulated by binding to the decoy receptors TNFRSF10C / TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis.
Source : E.coli
Species : Human
Predicted N Terminal : Thr 95
Form : Lyophilized from sterile PBS, pH 7.4.
Bio-activity : Measured by its binding ability in a functional ELISA.
Molecular Mass : The recombinant mature human TRAIL protein consists of 187 amino acids and has a calculated molecular mass of 21.6 KD.
Endotoxin : <1.0EU/ug, LAL method
Purity : >95% (SDS-PAGE)
Stability : Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage : Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 [ Homo sapiens ]
Official Symbol : TNFSF10
Synonyms : TNFSF10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor ligand superfamily member 10; Apo 2L; CD253; TL2; TRAIL; Apo-2 ligand; TNF-related apoptosis inducing ligand TRAIL; tumor necrosis factor (ligand) family, member 10; chemokine tumor necrosis factor ligand superfamily member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; APO2L; Apo-2L;
Gene ID : 8743
mRNA Refseq : NM_001190942
Protein Refseq : NP_001177871
MIM : 603598
UniProt ID : P50591
Chromosome Location : 3q26
Pathway : Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Caspase-8 is formed from procaspase-8, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem;
Function : cytokine activity; metal ion binding; protein binding; receptor binding; tumor necrosis factor receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What is the therapeutic potential of TNFSF10 protein? 11/21/2021

TNFSF10 protein holds great therapeutic potential as a target for various diseases. Studies have shown that utilizing its apoptosis-inducing ability, novel treatment strategies can be developed for cancer. Furthermore, TNFSF10 protein can be utilized in the design of immunotherapies to enhance immune responses. However, further research is needed to optimize TNFSF10 therapeutic strategies and gain a deeper understanding of its specific mechanisms in disease development.

What is the cellular source of TNFSF10 protein? 01/07/2019

The cellular source of TNFSF10 protein is diverse, including tumor cells, lymphocytes, monocytes, and dendritic cells. Additionally, some epithelial cells and endothelial cells also express TNFSF10 protein.

What is the physiological function of TNFSF10 protein in tissue remodeling? 03/07/2018

TNFSF10 protein has diverse physiological functions in tissue remodeling. It promotes inflammation, angiogenesis, and fibrosis processes. Moreover, TNFSF10 protein is involved in immune regulation and tissue repair, playing a crucial role in maintaining normal tissue functionality and structure.

What cellular processes are modulated by TNFSF10? 01/24/2018

TNFSF10 modulates multiple cellular processes beyond apoptosis induction. It can activate various signaling pathways, including the NF-κB pathway, which plays a key role in immune and inflammatory responses. TNFSF10 also regulates cell migration and invasion properties, affecting metastasis in some cancer types. Furthermore, TNFSF10 can promote immune cell activation and cytokine production, contributing to the regulation of the immune system.

What is the role of TNFSF10 protein in cancer progression and metastasis? 10/27/2017

TNFSF10 protein plays a significant role in cancer progression and metastasis. It induces apoptosis in tumor cells, inhibits tumor growth and metastasis, and regulates immune responses. Moreover, TNFSF10 protein interacts with other signaling pathways, participating in the modulation of the tumor microenvironment.

What are the transcriptional regulatory mechanisms of TNFSF10 protein? 10/23/2017

The transcriptional regulation of TNFSF10 gene involves various factors. Known regulators include transcription factors NF-κB, STAT3, and DNA methylation status. These factors modulate the expression levels of TNFSF10 gene, thereby influencing the production of TNFSF10 protein.

What are the substrate interactions of TNFSF10 protein? 04/23/2016

TNFSF10 protein interacts with its receptor, death receptor 5 (DR5), and triggers apoptosis pathway to induce cell death. Additionally, TNFSF10 protein also interacts with other ligands and receptors, such as TRAIL-R1 and TRAIL-R2, thereby regulating cell survival and death signaling transduction.

Customer Reviews (3)

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09/19/2021

    Its quality exceeding imagination, this experimental reagent becomes an indispensable tool for my experiments.

    04/07/2020

      Through its employment, I am able to delve deeper into the essence of experimental principles and phenomena.

      07/21/2017

        The exceptional performance of this experimental reagent significantly enhances the visibility of my research and amplifies my scholarly impact.

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