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Recombinant Human Transforming Growth Factor, beta 1

Cat.No. : TGFB1-126H
Product Overview : Recombinant human TGF-β1 protein was expressed in E.coli and purified by using conventional chromatography techniques. MW=12.9 kDa (113aa).
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Cat. No. : TGFB1-126H
Description : Transforming growth factor beta 1(TGF-β1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. Many cells synthesize TGFb1 and almost all of them have specific receptors for it. It positively and negatively regulates many other growth factors. Also, TGF-β1 plays an important role in bone remodeling, controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages.
Source : E. Coli.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Form : Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol.
Purity : > 95% by SDS-PAGE.
Endotoxin Level : < 1.0 EU per 1 μg of protein (determined by LAL method ).
Amino Acid Sequence : MALDTNYCFS STEKNCCVRQ LYIDFRKDLG WKWIHEPKGY HANFCLGPCP YIWSLDTQYS KVLALYNQHN PGASAAPCCV PQALEPLPIV YYVGRKPKVE QLSNMIVRSC KCS.
Storage : Can be stored at +4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20°Cor -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : TGFB1 transforming growth factor, beta 1 [ Homo sapiens ]
Synonyms : transforming growth factor, beta 1; CED; LAP; DPD1; TGFB; TGFbeta; TGFB1; TGF-beta 1 protein; latency-associated peptide; Camurati-Engelmann disease; TGF-beta-1; transforming growth factor-beta 1; diaphyseal dysplasia 1, progressive; TGF-beta 1 protein
Gene ID : 7040
mRNA Refseq : NM_000660
Protein Refseq : NP_000651
MIM : 190180
UniProt ID : P01137
Chromosome Location : 19q13.1
Pathway : Cell cycle; Chronic myeloid leukemia; Cytokine-cytokine receptor interaction; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; Renal cell carcinoma; TGF-beta signaling pathway; Influenza Infection; Signaling by TGF beta; Colorectal cancer; Hemostasis
Function : type II transforming growth factor beta receptor binding; transcription activator activity; protein homodimerization activity; protein heterodimerization activity; protein N-terminus binding; growth factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How is TGFB1 involved in bone remodeling? 08/04/2020

TGFB1 stimulates the activity of cells involved in bone formation (osteoblasts) and plays a role in regulating bone resorption by influencing osteoclast function.

Are there any side effects associated with therapies targeting TGFB1? 10/09/2019

Potential side effects of anti-TGFB1 therapies may include immune system suppression, gastrointestinal issues, and skin reactions.

Can TGFB1 be used as a biomarker for certain diseases? 04/11/2017

TGFB1 levels have been studied as potential biomarkers for diseases like cancer and fibrosis, aiding in diagnosis and monitoring disease progression.

In what ways does TGFB1 influence wound healing? 05/15/2016

TGFB1 plays a critical role in wound healing by stimulating the formation of new blood vessels, promoting the production of extracellular matrix, and aiding in the migration of cells to the wound site.

How does TGFB1 contribute to fibrosis? 05/06/2016

TGFB1 can induce the production of excessive extracellular matrix proteins, leading to tissue scarring and fibrosis in organs such as the liver, lung, and kidneys.

Customer Reviews (3)

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Reviews
11/16/2021

    The impressive performance of the TGFB1 protein both in ELISA assays and protein electron microscopy structure analysis makes it a highly versatile and recommended choice for scientists across various disciplines.

    03/01/2020

      Its reliability and efficacy in generating high-quality data make it an indispensable tool in the quest for unraveling the mysteries of protein structure and function.

      07/16/2018

        The TGFB1 protein's excellent performance in ELISA ensures accurate and reproducible results, enhancing the reliability of experimental data.

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