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Recombinant Human UBA1 Protein, His-tagged

Cat.No. : UBA1-337H
Product Overview : Full length Recombinant Human UBA1 (Ubiquitin-Like Modifier Activating Enzyme 1) Protein is produced in Insect Cells and is fused with a His tag at the N-terminal.
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Description : UBA1 (UniProt/Swiss-Prot entry P22314) is catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It activates ubiquitin by adenylating the C-terminal glycine residue with ATP and subsequently linking the adenylated glycine to the side chain of a cysteine residue in E1 thereby forming a ubiquitin-E1 thioester. UBA1 is also required for DNA repair response to replication stress.
Source : Insect Cells
Species : Human
Tag : His
Form : 20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.
Purity : Purified using FPLC, >95% purity as determined by SDS-PAGE.
Notes : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Stability : Guaranteed stable for 2 years from date of receipt when stored properly.
Storage : Store at -80 centigrade.
Concentration : 0.5 µg/µl
Gene Name : UBA1 ubiquitin-like modifier activating enzyme 1 [ Homo sapiens ]
Official Symbol : UBA1
Synonyms : UBA1; ubiquitin-like modifier activating enzyme 1; POC20; UBE1X; A1S9; A1ST; GXP1; UBE1; A1S9T; AMCX1; SMAX2; UBA1A; MGC4781;
Gene ID : 7317
mRNA Refseq : NM_003334
Protein Refseq : NP_003325
MIM : 314370
UniProt ID : P22314

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any clinical trials involving UBA1 as a target? 04/20/2023

Some early-phase clinical trials are exploring UBA1 as a potential target in the context of ALS and cancer.

How can UBA1 be targeted for therapeutic purposes? 09/19/2020

Targeting UBA1 with small molecules or gene therapy may provide a potential avenue for treating UBA1-related diseases.

How does UBA1 function in the cell? 12/04/2017

UBA1 activates ubiquitin, a small protein that tags other proteins for degradation by the proteasome.

What diseases are associated with UBA1 dysfunction? 07/19/2017

UBA1 dysfunction has been linked to neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and certain types of cancer.

Can UBA1 be a diagnostic marker for ALS? 08/16/2016

Research suggests that altered UBA1 levels in the cerebrospinal fluid may be a potential biomarker for ALS diagnosis.

Customer Reviews (3)

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Reviews
07/02/2022

    The UBA1 protein comes highly recommended for its outstanding performance in various experimental applications.

    07/07/2019

      In ELISA assays, it has consistently exhibited exceptional reliability and accuracy, providing precise and reproducible results.

      05/13/2017

        Their prompt and knowledgeable guidance has been instrumental in effectively addressing my queries and optimizing the utilization of the UBA1 protein in my studies.

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