Recombinant Human UBA1 Protein, His-tagged
Cat.No. : | UBA1-337H |
Product Overview : | Full length Recombinant Human UBA1 (Ubiquitin-Like Modifier Activating Enzyme 1) Protein is produced in Insect Cells and is fused with a His tag at the N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | UBA1 (UniProt/Swiss-Prot entry P22314) is catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It activates ubiquitin by adenylating the C-terminal glycine residue with ATP and subsequently linking the adenylated glycine to the side chain of a cysteine residue in E1 thereby forming a ubiquitin-E1 thioester. UBA1 is also required for DNA repair response to replication stress. |
Source : | Insect Cells |
Species : | Human |
Tag : | His |
Form : | 20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT. |
Purity : | Purified using FPLC, >95% purity as determined by SDS-PAGE. |
Notes : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Stability : | Guaranteed stable for 2 years from date of receipt when stored properly. |
Storage : | Store at -80 centigrade. |
Concentration : | 0.5 µg/µl |
Gene Name : | UBA1 ubiquitin-like modifier activating enzyme 1 [ Homo sapiens ] |
Official Symbol : | UBA1 |
Synonyms : | UBA1; ubiquitin-like modifier activating enzyme 1; POC20; UBE1X; A1S9; A1ST; GXP1; UBE1; A1S9T; AMCX1; SMAX2; UBA1A; MGC4781; |
Gene ID : | 7317 |
mRNA Refseq : | NM_003334 |
Protein Refseq : | NP_003325 |
MIM : | 314370 |
UniProt ID : | P22314 |
Products Types
◆ Recombinant Protein | ||
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UBA1-7333H | Recombinant Human UBA1 protein(Ser2-Arg1058), His&GST-tagged | +Inquiry |
UBA1-264H | Recombinant Human UBA1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Uba1-6764M | Recombinant Mouse Uba1 Protein, Myc/DDK-tagged | +Inquiry |
UBA1-212H | Recombinant Human UBA1 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
UBA1-420HCL | Recombinant Human UBA1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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- Reviews
Q&As (5)
Ask a questionSome early-phase clinical trials are exploring UBA1 as a potential target in the context of ALS and cancer.
Targeting UBA1 with small molecules or gene therapy may provide a potential avenue for treating UBA1-related diseases.
UBA1 activates ubiquitin, a small protein that tags other proteins for degradation by the proteasome.
UBA1 dysfunction has been linked to neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and certain types of cancer.
Research suggests that altered UBA1 levels in the cerebrospinal fluid may be a potential biomarker for ALS diagnosis.
Customer Reviews (3)
Write a reviewThe UBA1 protein comes highly recommended for its outstanding performance in various experimental applications.
In ELISA assays, it has consistently exhibited exceptional reliability and accuracy, providing precise and reproducible results.
Their prompt and knowledgeable guidance has been instrumental in effectively addressing my queries and optimizing the utilization of the UBA1 protein in my studies.
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