Recombinant Human UBE2K Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: UBE2K-4276H
• Product Overview: UBE2K MS Standard C13 and N15-labeled recombinant protein (NP_005330) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 22.2 kDa
• AA Sequence: MANIAVQRIKREFKEVLKSEETSKN QIKVDLVDENFTELRGEIAGPPDTP YEGGRYQLEIKIPETYPFNPPKVRF ITKIWHPNISSVTGAICLDILKDQW AAAMTLRTVLLSLQALLAAAEPDDP QDAVVANQYKQNPEMFKQTARLWAH VYAGAPVSSPEYTKKIENLCAMGFD RNAVIVALSSKSWDVETATELLLSN TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: UBE2K ubiquitin-conjugating enzyme E2K [ Homo sapiens (human) ]
• Official Symbol: UBE2K
• Synonyms: UBE2K; ubiquitin-conjugating enzyme E2K; HIP2, huntingtin interacting protein 2, ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast); ubiquitin-conjugating enzyme E2 K; HYPG; UBC1; HIP-2; E2(25K); ubiquitin-protein ligase; ubiquitin carrier protein; huntingtin interacting protein 2; huntingtin-interacting protein 2; ubiquitin-conjugating enzyme E2-25K; ubiquitin-conjugating enzyme E2(25K); ubiquitin-conjugating enzyme E2-25 KDA; ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); LIG; HIP2; E2-25K; DKFZp564C1216; DKFZp686J24237
• Gene ID: 3093
• mRNA Refseq: NM_005339
• Protein Refseq: NP_005330
• MIM: 602846
• UniProt ID: P61086