Recombinant Human UGT1A10 Protein UGT1A10-101H

Recombinant Human UGT1A10 Protein

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Recombinant Human UGT1A10 Protein

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Cat.No. : UGT1A10-101H
Product Overview : Recombinant human UGT1A10 protein without tag was expressed in insect cells.
Description : This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.
Source : Insect cells
Species : Human
Bio-activity : UGT Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 100 mM Tris-HCl (pH 7.5) containing 5 mM magnesium chloride and 2 mM UDPGA. Alamethicin (10 μg/ml final concentration) is added to kinetics tests only)
Substrate: 4-methylumbelliferone
Linear with time up to: 15 min(Determined at 2 μM substrate, using a protein concentration of 5 μg/ml)
Linear with protein up to: 50 μg/ml(Determined at 2 μM substrate, using an incubation time of 5 min)
Vmax: 7129 pmol/min/mg protein
Km: 5.4 μM
Usage : For laboratory (research) purposes only
Storage : Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice.
Concentration : Protein Concentration: 5 mg/ml
Storage Buffer : 25 mM Tris-acetate (pH 7.6), 10% (v/v) glycerol, 1 mM EDTA
Gene Name : UGT1A10 UDP glucuronosyltransferase family 1 member A10 [ Homo sapiens (human) ]
Official Symbol : UGT1A10
Synonyms : UGT1A10; UDP glucuronosyltransferase family 1 member A10; GNT1; UGT1; UDPGT; UGT1A; UGT1J; UGT-1A; UGT-1J; UGT1.1; UGT1A1; UGT1-01; UGT1-10; UGT1.10; hUG-BR1; UDP-glucuronosyltransferase 1-10; Bilirubin-specific UDPGT isozyme 1; UDP glucuronosyltransferase 1 family, polypeptide A10; UDP glycosyltransferase 1 family, polypeptide A10; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1-J; UDP-glucuronosyltransferase 1A1; UDP-glucuronosyltransferase 1A10; UDPGT 1-1; UDPGT 1-10
Gene ID : 54575
mRNA Refseq : NM_019075
Protein Refseq : NP_061948
MIM : 606435
UniProt ID : Q9HAW8
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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