Recombinant Human USP2 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human USP2 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : USP2-886H
Product Overview : USP2 MS Standard C13 and N15-labeled recombinant protein (NP_741994) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 45.1 kDa
AA Sequence : MRTSYTVTLP EDPPAAPFPA LAKELRPRSP LSPSLLLSTF VGLLLNKAKN SKSAQGLAGL RNLGNTCFMN SILQCLSNTR ELRDYCLQRL YMRDLHHGSN AHTALVEEFA KLIQTIWTSS PNDVVSPSEF KTQIQRYAPR FVGYNQQDAQ EFLRFLLDGL HNEVNRVTLR PKSNPENLDH LPDDEKGRQM WRKYLEREDS RIGDLFVGQL KSSLTCTDCG YCSTVFDPFW DLSLPIAKRG YPEVTLMDCM RLFTKEDVLD GDEKPTCCRC RGRKRCIKKF SIQRFPKILV LHLKRFSESR IRTSKLTTFV NFPLRDLDLR EFASENTNHA VYNLYAVSNH SGTTMGGHYT AYCRSPGTGE WHTFNDSSVT PMSSSQVRTS DAYLLFYELA SPPSRMTRTR PLEQKLISEE DLAANDILDY KDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : USP2 ubiquitin specific peptidase 2 [ Homo sapiens (human) ]
Official Symbol : USP2
Synonyms : USP2; ubiquitin specific peptidase 2; ubiquitin specific protease 2; ubiquitin carboxyl-terminal hydrolase 2; UBP41; ubiquitin thioesterase 2; deubiquitinating enzyme 2; ubiquitin specific protease 9; ubiquitin specific protease 12; 41 kDa ubiquitin-specific protease; ubiquitin-specific-processing protease 2; USP9;
Gene ID : 9099
mRNA Refseq : NM_171997
Protein Refseq : NP_741994
MIM : 604725
UniProt ID : O75604

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