"WISP1" Related Products

Expand
Expand

Recombinant Human WISP1 Protein, His-tagged

Cat.No.: WISP1-592H
Product Overview: Recombinant Human WISP1(Cys216~Arg347) fused with His tag at N-terminal was expressed in E. coli.
Description: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.
Source: E. coli
Species: Human
Tag : His
Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass: 18.33kDa
Protein length: Cys216~Arg347
Endotoxin: <1.0EU per 1µg (determined by the LAL method)
Purity: > 92%
Applications: Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein.
Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution: Reconstitute in PBS or others.
Gene Name: WISP1 WNT1 inducible signaling pathway protein 1 [ Homo sapiens ]
Official Symbol: WISP1
Synonyms: WISP1; WNT1 inducible signaling pathway protein 1; WNT1-inducible-signaling pathway protein 1; CCN4; CCN family member 4; WNT1 induced secreted protein 1; Wnt-1 inducible signaling pathway protein 1; WISP1c; WISP1i; WISP1tc; FLJ14388;
Gene ID: 8840
mRNA Refseq: NM_001204869
Protein Refseq: NP_001191798
MIM: 603398
UniProt ID: O95388

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.