Recombinant Humancytotoxic T-lymphocyte-Associated Protein 4
Cat.No. : | CTLA4-137H |
Product Overview : | Recombinant Human Cytotoxic T-Lymphocyte Associated Antigen-4 produced in insect cells is a homodimeric, glycosylated, polypeptide chain containing a total molecular mass of 80 kDa. Each subunit (40kDa) is fused to a polypeptide linker to the Fc portion of Human IgG1. CTLA4 is expressed in low copy number by T-cells only after activation, but it binds CD28-ligand with approximately 20-fold higher affinity than CD28. A soluble form of the extracellular domain of CTLA-4 has been shown to bind CD28-ligand with high avidity and to suppress T-cell-dependent antibody responses in vivo. Large doses of this soluble protein also suppress responses to a second immunization. CTLA-4 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CTLA4-137H |
Description : | CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bon. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. |
Source : | Sf9 cells. |
Amino Acid Sequence : | The sequence of the amino acids was determined and was found to be: Lys-Ala-Met-His-Val. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Formulation : | CTLA-4 was lyophilized with no additives. |
Solubility : | It is recommended to reconstitute the lyophilized Cytotoxic T-Lymphocyte Associated Antigen-4 Human in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
Stability : | Lyophilized Cytotoxic T-Lymphocyte Associated Antigen Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CTLA-4 should be stored at 4°C between 2-7 days and for future use below -18 °C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens ] |
Synonyms : | CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; CD28; CD152; CD_antigen=CD152; CELIAC3; CTLA-4; celiac disease 3; Cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; ICOS; GSE; ICOS; IDDM12; IDDM12; Short name=CTLA-4; OTTHUMP00000163781; |
Gene ID : | 1493 |
mRNA Refseq : | NM_001037631 |
Protein Refseq : | NP_001032720 |
MIM : | 123890 |
UniProt ID : | P16410 |
Chromosome Location : | 2q33 |
Pathway : | Autoimmune thyroid disease ; Cell adhesion molecules (CAMs); T cell receptor signaling pathway |
Function : | Protein binding |
Products Types
◆ Recombinant Protein | ||
Ctla4-651H | Recombinant Human Ctla4 Protein, IgG2a Fc-tagged | +Inquiry |
CTLA4-1106H | Recombinant Human CTLA4 Protein (Met1-Phe162), HlgG1 Fc-tagged, Biotinylated | +Inquiry |
Ctla4-652H | Recombinant Human Ctla4 Protein, Strep-tagged | +Inquiry |
CTLA4-648C | Recombinant Cynomolgus monkey CTLA4 Protein, Fc-tagged | +Inquiry |
Ctla4-158M | Recombinant Mouse Ctla4 Protein, His (Fc)-Avi-tagged | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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