Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Mouse Add2 Protein, MYC/DDK-tagged

Cat.No. : Add2-540M
Product Overview : Purified recombinant protein of full-length mouse adducin 2 (beta), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes the beta subunit of the adducin family. Adducins, encoded by alpha, beta and gamma genes, are heteromeric proteins that crosslink actin filaments with spectrin at the cytoskeletal membrane. This protein, primarily found in the brain and hematopoietic cells, is regulated by phosphorylation and calmodulin interactions as it promotes spectrin assembly onto actin filaments, bundles actin and caps barbed ends of actin filaments. In mouse, deficiency of this gene can lead to mild hemolytic anemia and impaired synaptic plasticity. Mutations of this gene in mouse serve as a pathophysiological model for hereditary spherocytosis and hereditary elliptocytosis. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 62.8 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Add2 adducin 2 (beta) [ Mus musculus (house mouse) ]
Official Symbol : Add2
Synonyms : Add2; adducin 2 (beta); add97; 2900072M03Rik; beta-adducin; erythrocyte adducin subunit beta; snoRNA MBII-396
Gene ID : 11519
mRNA Refseq : NM_013458
Protein Refseq : NP_038486
UniProt ID : Q9QYB8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (10)

Ask a question
Are there any small molecules or drugs that can selectively modulate the activity or stability of ADD2? 09/20/2022

There may exist small molecules or drugs that selectively modulate the activity or stability of ADD2.

Are there specific interacting proteins or binding partners that associate with ADD2 in a cell- or context-specific manner? 05/19/2021

ADD2 interacts with specific proteins or binding partners, and these interactions can be context-dependent.

What is the expression profile of ADD2 in different tissues and cell types? 04/27/2020

The expression profile of ADD2 varies across different tissues and cell types.

What are the downstream signaling pathways or target molecules regulated by ADD2, and how do they contribute to its cellular functions? 02/16/2020

ADD2 regulates downstream signaling pathways or target molecules that contribute to its cellular functions.

Can specific antibodies or probes be developed to visualize the localization or dynamics of ADD2 in live cells or tissues? 05/07/2019

Specific antibodies or probes can be developed to visualize the localization or dynamics of ADD2 in live cells or tissues.

What post-translational modifications, such as phosphorylation or ubiquitination, occur on ADD2 and how do they impact its function? 02/15/2017

Post-translational modifications, such as phosphorylation or ubiquitination, occur on ADD2 and can influence its function.

Can the functional domains or motifs within ADD2 be identified and characterized? 02/06/2017

Functional domains or motifs within ADD2 can be identified and characterized.

How is the expression of ADD2 regulated during development or in response to specific stimuli? 07/30/2016

The expression of ADD2 can be regulated during development or in response to specific stimuli.

What are the consequences of modulating the expression or activity of ADD2 on cellular processes like cytoskeletal organization, cell motility, or membrane dynamics? 07/15/2016

Modulating the expression or activity of ADD2 can impact cellular processes like cytoskeletal organization, cell motility, or membrane dynamics.

What is the subcellular localization of ADD2 within cells? Does it exhibit any dynamic localization or translocation? 07/07/2016

ADD2 exhibits subcellular localization, and its localization may undergo dynamic changes or translocation.

Customer Reviews (2)

Write a review
Reviews
12/07/2021

    Highly sensitive in bioactivity assays, accurately detecting the activity and concentration of bioactive factors.

    05/31/2017

      Provides accurate and reliable quantification of protein biomarkers in clinical samples.

      Ask a Question for All Add2 Products

      Required fields are marked with *

      My Review for All Add2 Products

      Required fields are marked with *

      0

      Inquiry Basket

      cartIcon
      logo

      FOLLOW US

      Terms and Conditions        Privacy Policy

      Copyright © 2024 Creative BioMart. All Rights Reserved.

      Contact Us

      • /

      Stay Updated on the Latest Bioscience Trends