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Recombinant Mouse Aifm2 Protein, Myc/DDK-tagged

Cat.No. : Aifm2-1574M
Product Overview : Purified recombinant protein of mouse full-length apoptosis-inducing factor, mitochondrion-associated 2 (Aifm2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Biased expression in adrenal adult (RPKM 65.8), bladder adult (RPKM 44.5) and 13 other tissues
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 36.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Aifm2 apoptosis-inducing factor, mitochondrion-associated 2 [ Mus musculus (house mouse) ]
Official Symbol : Aifm2
Synonyms : AIFM2; apoptosis-inducing factor, mitochondrion-associated 2; apoptosis-inducing factor 2; apoptosis-inducing factor-like mitchondrion-associated inducer of death; apoptosis-inducing factor-like mitochondrion-associated inducer of death; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor homologous mitochondrion-associated inducer of death; Amid; PRG3; 5430437E11Rik; D730001I10Rik
Gene ID : 71361
mRNA Refseq : NM_153779
Protein Refseq : NP_722474
UniProt ID : Q8BUE4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (12)

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What are AIFM2 inhibitors, and how are they used in research? 05/08/2023

AIFM2 inhibitors are compounds that inhibit the activity of AIFM2 protein. These inhibitors are being developed as potential therapeutics for diseases such as cancer and neurodegenerative disorders. In research, AIFM2 inhibitors are used to study the role of AIFM2 in cellular processes and to investigate the effects of inhibiting AIFM2 activity on disease outcomes.

Can changes in AIFM2 expression levels lead to disease states? 04/26/2023

Yes, changes in AIFM2 expression levels have been associated with several disease states. For example, decreased expression of AIFM2 has been linked with increased oxidative stress and mitochondrial dysfunction, which are both implicated in neurodegenerative disorders such as Alzheimer's and Parkinson's disease.

Is AIFM2 protein involved in neuronal death and neurodegenerative diseases? 02/09/2023

Yes, AIFM2 protein has been shown to play a role in neuronal death and neurodegenerative diseases. AIFM2 is localized in the mitochondria and is involved in regulating mitochondrial function, which is critical for maintaining neuronal homeostasis. Dysregulation of AIFM2 has been observed in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, and has been associated with neuronal death.

How is AIFM2 expression regulated? 10/06/2021

AIFM2 expression is regulated at the transcriptional level by various transcription factors, including ATF4 and GABP. It can also be regulated at the post-transcriptional level by microRNAs, which can target the AIFM2 mRNA for degradation or inhibit its translation. In addition, AIFM2 expression can be influenced by cellular stress and disease states, which can impact its localization and activity.

What are the therapeutic implications of AIFM2 in neurodegenerative diseases? 05/27/2021

The dysregulation of AIFM2 in neurodegenerative diseases implicates it as a potential therapeutic target. Targeting AIFM2 activity could potentially attenuate the neuronal death and degeneration observed in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. AIFM2 inhibitors are being developed as potential therapeutics for these conditions.

How is AIFM2 protein related to cancer? 09/11/2018

AIFM2 protein has been shown to play a role in cancer by regulating apoptosis and cell survival. Decreased expression of AIFM2 has been observed in several types of cancer, including breast, prostate, and colon cancer. This decreased expression is thought to contribute to the development and progression of cancer by inhibiting apoptosis and promoting cell survival.

How is the activity of AIFM2 protein regulated? 04/24/2018

The activity of AIFM2 protein is regulated by its subcellular localization, post-translational modifications, and interaction with other proteins. The protein contains a conserved N-terminal mitochondrial targeting sequence that directs it to the mitochondria. The activity of AIFM2 protein can be regulated by phosphorylation, acetylation, and S-nitrosylation, as well as by the binding of other proteins.

Can AIFM2 protein be a potential therapeutic target for diseases? 11/13/2017

Yes, AIFM2 protein is a potential therapeutic target for several diseases, including neurodegenerative disorders and cancer. Strategies such as small molecule inhibitors or gene therapy to regulate AIFM2 activity could be explored as potential therapeutic approaches. However, further research is needed to assess the safety and efficacy of such interventions.

Are there any genetic mutations associated with AIFM2 protein? 09/07/2017

Yes, several genetic mutations have been identified in the AIFM2 gene that are associated with diseases. For example, a mutation in the AIFM2 gene has been linked to an autosomal recessive disorder characterized by deafness, optic neuropathy, and muscle weakness.

Can AIFM2 protein be used as a biomarker for diseases? 08/25/2016

AIFM2 protein has been identified as a potential biomarker for several diseases, including neurodegenerative disorders and cancer. Changes in AIFM2 expression levels have been observed in these diseases, and measuring AIFM2 levels in biological samples such as blood or cerebrospinal fluid may provide a non-invasive way to monitor disease progression or response to treatment.

Can AIFM2 be used as a target for cancer therapy? 07/07/2016

Yes, AIFM2 has emerged as a potential target for cancer therapy. Modulating AIFM2 expression or activity has been shown to impact cancer cell survival and proliferation, and AIFM2 inhibitors are being developed as potential therapeutics. Clinical trials are ongoing to evaluate the safety and efficacy of these inhibitors in cancer patients.

How is AIFM2 involved in oxidative stress? 07/14/2015

AIFM2 plays a role in regulating oxidative stress in cells. It is involved in maintaining mitochondrial function and regulating ROS levels. Dysregulation of AIFM2 has been associated with increased cellular oxidative stress, which can contribute to the pathogenesis of various diseases such as cancer and neurodegenerative disorders.

Customer Reviews (3)

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Reviews
04/25/2020

    Their prompt and reliable assistance enables me to navigate through protocols, troubleshoot issues, and interpret complex data, ensuring the successful completion of my research goals.

    11/22/2017

      the exceptional quality of the AIFM2 protein, combined with the manufacturer's exceptional technical support, positions it as an invaluable asset for my experimental endeavors.

      12/30/2016

        With their extensive knowledge and expertise, they are well-equipped to address any challenges or inquiries that may arise during my experiments.

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