Recombinant Mouse ALS2 Protein
Cat.No. : | ALS2-1577M |
Product Overview : | Recombinant Mouse ALS2 full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian Cells |
Species : | Mouse |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC. |
Storage Buffer : | PBS buffer |
Gene Name : | Als2 amyotrophic lateral sclerosis 2 (juvenile) [ Mus musculus ] |
Official Symbol : | ALS2 |
Gene ID : | 74018 |
mRNA Refseq : | NM_001159948.2 |
Protein Refseq : | NP_001153420.2 |
MIM : | |
UniProt ID : | Q920R0 |
Products Types
◆ Recombinant Protein | ||
ALS2-491M | Recombinant Mouse ALS2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALS2-298R | Recombinant Rat ALS2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Als2-3402R | Recombinant Rat Als2, His-tagged | +Inquiry |
ALS2-9600H | Recombinant Human ALS2, His-tagged | +Inquiry |
ALS2-642R | Recombinant Rat ALS2 Protein | +Inquiry |
◆ Lysates | ||
ALS2-66HCL | Recombinant Human ALS2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALS2 contains functional domains, including RhoGAP and VPS9 domains, which contribute to its GTPase activity, protein interactions, or membrane association.
ALS2 plays a role in regulating axonal growth, neurite outgrowth, or cytoskeletal organization, potentially influencing neuronal development and connectivity.
ALS2 exhibits a predominantly cytoplasmic localization, with possible associations with endosomes, the Golgi apparatus, or cytoskeletal structures.
Dysregulation or mutations in ALS2 can contribute to motor neuron degeneration in ALS, a progressive neurodegenerative disorder characterized by the selective loss of motor neurons in the brain and spinal cord.
ALS2 expression levels can vary among different tissues and cell types, and they are regulated by factors such as developmental cues, cellular stress, or specific signaling pathways.
Genetic variations or mutations in ALS2 have been associated with juvenile forms of ALS and hereditary spastic paraplegia, suggesting their impact on ALS2 function and disease pathogenesis.
ALS2 interacts with various proteins involved in vesicle trafficking, cytoskeletal dynamics, or signaling cascades, forming complexes critical for its functional roles.
Post-translational modifications, such as phosphorylation or acetylation, can regulate ALS2 function, stability, or interactions with other proteins.
Targeting ALS2 or its associated pathways may offer potential therapeutic strategies for ALS and related motor neuron disorders, aiming to restore neuronal connectivity, enhance vesicle trafficking, or alleviate cellular stress in affected motor neurons.
ALS2 modulates signaling pathways, such as the Rho GTPase signaling pathway, which are involved in cytoskeletal dynamics, vesicle transport, or cellular responses to extracellular signals.
Customer Reviews (3)
Write a reviewRobust antibody for immunoprecipitation experiments.
Excellent signal-to-noise ratio in assays.
Accurate determination of protein-protein interaction kinetics.
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