Recombinant Mouse AMH Protein (450-552 aa), His-tagged
Cat.No. : | AMH-1327M |
Product Overview : | Recombinant Mouse AMH Protein (450-552 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Partial. |
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- Gene Information
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Description : | This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. |
Source : | Yeast |
Species : | Mouse |
Tag : | His |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 13.3 kDa |
Protein length : | 450-552 aa |
AA Sequence : | DKGQDGPCALRELSVDLRAERSVLI PETYQANNCQGACRWPQSDRNPRYG NHVVLLLKMQARGAALGRLPCCVPT AYAGKLLISLSEERISADHVPNMVA TEC |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |
Gene Name : | Amh anti-Mullerian hormone [ Mus musculus ] |
Official Symbol : | AMH |
Synonyms : | AMH; anti-Mullerian hormone; MIS; |
Gene ID : | 11705 |
mRNA Refseq : | NM_007445 |
Protein Refseq : | NP_031471 |
UniProt ID : | P27106 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMH interacts with hormones like FSH and estrogen to modulate the balance between follicular development and follicle selection.
AMH expression is influenced by genetic variations and epigenetic modifications that can contribute to inter-individual differences in AMH levels.
AMH inhibits the development of M眉llerian ducts in males, promoting the differentiation of Sertoli cells and the formation of the male reproductive system.
Deficiency or overexpression of AMH can lead to reproductive abnormalities, such as altered fertility, impaired gonadal development, or disorders of sexual differentiation.
In females, AMH plays a role in regulating the regression of M眉llerian ducts and inhibiting follicular development.
Modulating AMH signaling pathways may hold therapeutic potential for infertility treatments and the management of reproductive disorders by manipulating follicular development or regulating reproductive organ development.
Dysregulation of AMH has been associated with reproductive disorders, including polycystic ovary syndrome (PCOS) characterized by increased AMH levels, and disorders of sexual development (DSD) associated with AMH deficiency or insensitivity.
AMH levels can serve as a valuable biomarker for assessing ovarian reserve and predicting ovarian response to fertility treatments like in vitro fertilization (IVF).
AMH expression is tightly regulated during gonadal development and sex determination, primarily controlled by the transcription factors involved in testis development, such as SRY (Sex-determining Region Y) protein.
AMH activates the transforming growth factor-beta (TGF-尾) signaling pathway, which plays a crucial role in regulating reproductive organ development and functions.
Customer Reviews (3)
Write a reviewReduced assay optimization time for faster results.
High-throughput compatibility for efficient data acquisition.
Stable reagents for long-term assay reproducibility.
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