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Recombinant Mouse Arhgef1 Protein, MYC/DDK-tagged

Cat.No. : Arhgef1-1298M
Product Overview : Purified recombinant protein of full-length mouse Rho guanine nucleotide exchange factor (GEF) 1 (Arhgef1), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.
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  • Gene Information
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Description : Broad expression in thymus adult (RPKM 202.0), spleen adult (RPKM 157.1) and 26 other tissues
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 102.8 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Arhgef1 Rho guanine nucleotide exchange factor (GEF) 1 [ Mus musculus (house mouse) ]
Official Symbol : Arhgef1
Synonyms : Arhgef1; Rho guanine nucleotide exchange factor (GEF) 1; Lsc; Lbcl2; rho guanine nucleotide exchange factor 1; lbc's second cousin; lymphoid blast crisis-like 2
Gene ID : 16801
mRNA Refseq : NM_001130152
Protein Refseq : NP_001123624
UniProt ID : Q61210

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (21)

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Can the ARHGEF1 protein interact with receptors or signaling pathways involved in immune responses? 04/28/2023

Yes, the ARHGEF1 protein can interact with receptors and signaling pathways involved in immune responses. For example, it has been shown to interact with Toll-like receptors (TLRs) and integrins, which are key players in immune cell activation and recruitment. ARHGEF1's involvement in immune responses may contribute to immune cell migration, adhesion, and cytokine production.

Is the ARHGEF1 gene conserved across different species? 03/26/2023

Yes, the ARHGEF1 gene is conserved across different species. Homologs of ARHGEF1 have been identified in various organisms, including mammals, birds, fish, worms, and insects. This conservation suggests that ARHGEF1 performs essential functions across different species, although the precise roles and regulation of ARHGEF1 may vary among different organisms.

Is there any evidence of ARHGEF1 involvement in neurological disorders? 02/12/2023

Yes, there is evidence suggesting a potential involvement of ARHGEF1 in neurological disorders. Studies have shown that ARHGEF1 is expressed in neurons and is involved in processes such as axonal guidance and neurite outgrowth, which are crucial for proper neuronal development. Furthermore, genetic variations in ARHGEF1 have been associated with an increased risk of developing neurodevelopmental disorders such as autism spectrum disorder (ASD) and intellectual disabilities. However, further research is needed to understand the specific mechanisms by which ARHGEF1 contributes to these disorders.

Are there any known crosstalk or interactions between ARHGEF1 and other signaling pathways? 11/13/2022

Yes, there is evidence of crosstalk and interactions between ARHGEF1 and other signaling pathways. For example, ARHGEF1 has been shown to interact with the Wnt signaling pathway, regulating cellular responses such as axon guidance and neurite outgrowth. Furthermore, ARHGEF1 can be modulated by other signaling pathways, like receptor tyrosine kinases or G protein-coupled receptors, to integrate multiple cellular signals.

Does ARHGEF1 play a role in neuronal development or synaptic plasticity? 06/18/2022

Yes, ARHGEF1 has been implicated in neuronal development and synaptic plasticity. It is expressed in neurons and has been shown to regulate cytoskeletal dynamics, which are crucial for neuronal migration, axon guidance, and dendritic arborization. Additionally, ARHGEF1 can modulate synaptic plasticity by influencing the formation and stabilization of dendritic spines.

Are there any drugs or therapeutic targets specifically related to the ARHGEF1 protein? 01/26/2022

Currently, there are no drugs or therapeutic targets specifically targeting the ARHGEF1 protein. However, since it plays a role in Rho GTPase signaling pathways, which are involved in various diseases, targeting downstream effectors of Rho GTPases might indirectly modulate ARHGEF1's function. Further research is needed to identify specific therapeutic strategies related to ARHGEF1.

Are there any diseases or disorders associated with dysregulation of the ARHGEF1 gene or protein? 06/04/2020

Dysregulation of the ARHGEF1 gene or protein has been implicated in certain diseases and disorders. Studies have suggested its involvement in cancer metastasis, cardiovascular diseases, and neurological disorders, such as Alzheimer's disease and schizophrenia. However, further research is needed to fully understand the significance and mechanisms of ARHGEF1 in these conditions.

Can ARHGEF1 interact with other proteins to exert its function? 05/24/2019

Yes, ARHGEF1 can interact with several proteins to exert its function in regulating Rho GTPases. It can interact with Rho GTPases themselves, as well as with other guanine nucleotide exchange factors, GTPase-activating proteins, and downstream effectors of Rho GTPases. These protein-protein interactions are important for the regulation of Rho GTPase signaling pathways and cellular processes.

Are there any known genetic variations or mutations in the ARHGEF1 gene associated with inherited disorders? 04/02/2018

To date, there are no specific inherited disorders associated with genetic variations or mutations in the ARHGEF1 gene. However, considering its role in various cellular processes, it is possible that future research may uncover such associations.

Are there any known drugs or therapeutic targets directly related to ARHGEF1? 02/17/2018

Currently, there are no known drugs or therapeutic targets specifically targeting ARHGEF1. However, since ARHGEF1 plays a role in Rho GTPase signaling, targeting Rho GTPases themselves or other key components of the Rho signaling pathway may indirectly modulate ARHGEF1 activity. Some therapeutic approaches targeting Rho GTPases are being explored for various diseases, but they are not specific to ARHGEF1.

Can ARHGEF1 play a role in neuronal plasticity and learning and memory processes? 02/17/2018

While the exact role of ARHGEF1 in neuronal plasticity, learning, and memory processes is not fully understood, there is some evidence suggesting its potential involvement. ARHGEF1 has been detected in the brain regions associated with learning and memory. Additionally, studies have shown that Rho GTPases, which are regulated by ARHGEF1, play crucial roles in dendritic spine morphology, synaptic plasticity, and memory formation. Further research is needed to elucidate the specific contribution of ARHGEF1 in these processes.

What are the physiological functions of ARHGEF1 in non-human organisms? 01/13/2018

The physiological functions of ARHGEF1 in non-human organisms are not extensively studied. However, studies in model organisms such as mice and flies have provided some insights. In mice, ARHGEF1 deficiency has been associated with abnormalities in T cell development and migration. In fruit flies, ARHGEF1 plays a role in cell motility and muscle development. Further investigation is needed to understand the full range of physiological functions of ARHGEF1 in non-human organisms.

Can ARHGEF1 be phosphorylated and how does phosphorylation affect its function? 06/26/2017

Yes, ARHGEF1 can undergo phosphorylation, which can modulate its function. Phosphorylation of specific residues in ARHGEF1 can affect its activity as a guanine nucleotide exchange factor and alter its interactions with other proteins. Phosphorylation can be regulated by various signaling pathways and kinases, thereby modulating ARHGEF1-mediated Rho GTPase activation and downstream cellular processes.

Are there any known natural ligands or molecules that interact with ARHGEF1? 06/14/2017

Currently, there are no well-characterized natural ligands specific to ARHGEF1. However, given its role as a guanine nucleotide exchange factor for Rho GTPases, it can interact with the GTP-bound form of Rho proteins and facilitate nucleotide exchange. Additionally, other proteins involved in Rho GTPase signaling pathways may indirectly interact with ARHGEF1.

Is the expression of the ARHGEF1 gene regulated differently in different tissues or cell types? 06/10/2017

Yes, the expression of the ARHGEF1 gene can be regulated differently in different tissues or cell types. It has been observed to have tissue-specific expression patterns, with higher expression in certain cell types such as neurons and immune cells. The regulation of its expression can be influenced by tissue-specific transcription factors and signaling pathways.

Is the ARHGEF1 gene conserved across different species? 05/16/2017

The ARHGEF1 gene is highly conserved across various species, including humans, mice, rats, and chickens. This conservation suggests its importance in fundamental cellular processes and highlights its evolutionary significance.

Has the ARHGEF1 gene been studied in the context of cardiovascular diseases? 04/24/2017

There is limited research on the specific role of ARHGEF1 in cardiovascular diseases. However, considering the involvement of Rho GTPases in cardiovascular processes such as vascular smooth muscle contraction, endothelial cell function, and cardiac remodeling, it is plausible that ARHGEF1 may play a role in cardiovascular health. Further studies are needed to determine the extent of ARHGEF1's involvement in cardiovascular diseases.

Can ARHGEF1 expression be influenced by environmental factors or external stimuli? 03/27/2017

While limited research has been done on the specific environmental factors or external stimuli that can influence ARHGEF1 expression, it is known that ARHGEF1 expression can be regulated by various signaling pathways activated by extracellular molecules. For example, in immune cells, ARHGEF1 expression can be upregulated upon stimulation with pro-inflammatory cytokines or bacterial products. Further studies are needed to determine the exact environmental factors that can modulate ARHGEF1 expression.

In which cellular compartments is the ARHGEF1 protein localized? 08/10/2016

The ARHGEF1 protein is primarily localized in the cytoplasm of cells. It interacts with Rho GTPases in the cytoplasm to facilitate their activation and downstream signaling.

Are there any known functional consequences of ARHGEF1 mutations or dysregulation? 02/28/2016

The functional consequences of ARHGEF1 mutations or dysregulation are not well-characterized. However, based on its role as a guanine nucleotide exchange factor for Rho GTPases, it is likely that ARHGEF1 mutations or dysregulation can disrupt Rho GTPase signaling, affecting cellular processes such as cell migration, adhesion, and cytoskeletal dynamics. Dysregulation of ARHGEF1 has been associated with increased cell invasiveness and angiogenesis in cancer cells, suggesting potential consequences on tumor progression.

Has the ARHGEF1 protein been studied in the context of cancer progression or metastasis? 01/16/2016

Yes, the ARHGEF1 protein has been studied in the context of cancer progression and metastasis. Dysregulation of ARHGEF1 has been linked to increased cell migratory and invasive properties in cancer cells. It may play a role in the rearrangement of the actin cytoskeleton, promoting the formation of invadopodia and facilitating cancer cell invasion into surrounding tissues. However, further research is needed to fully understand its involvement in cancer metastasis.

Customer Reviews (8)

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Reviews
10/17/2022

    By using ARHGEF1 protein, I can explore the mechanisms underlying cell division, cell cycle control, and the molecular pathways associated with these processes.

    02/26/2021

      One major advantage of ARHGEF1 protein is its ability to contribute to the understanding of diseases related to aberrant cell cycle regulation, including cancer.

      01/11/2021

        The manufacturer can provide researchers with a high-quality, purified form of ARHGEF1 protein, ensuring its integrity and functionality for experimental use.

        09/10/2020

          If researchers require modifications or specific variants of ARHGEF1 protein for their experiments, the manufacturer could potentially offer custom protein engineering services to meet their needs.

          02/27/2018

            As a researcher utilizing ARHGEF1 protein in my trials, I can highlight its advantages and the valuable support provided by the manufacturer in facilitating my research.

            10/24/2017

              In some cases, manufacturers may be open to collaborating with researchers to further investigate the applications and potential of ARHGEF1 protein.

              08/14/2017

                The protein's interaction with other APC/C subunits enables the study of its function and the investigation of its involvement in various cellular processes.

                09/05/2016

                  a manufacturer with a responsive and dedicated customer support team can address any concerns or queries that researchers may have.

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