Recombinant Mouse Arih2 Protein, Myc/DDK-tagged
Cat.No. : | Arih2-1700M |
Product Overview : | Purified recombinant protein of mouse full-length ariadne RBR E3 ubiquitin protein ligase 2 (Arih2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex. Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 57.7 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Arih2 ariadne RBR E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Arih2 |
Synonyms : | ARIH2; ariadne homolog 2 (Drosophila); E3 ubiquitin-protein ligase ARIH2; ARI-2; ariadne 2; protein ariadne-2 homolog; ubcM4-interacting protein 48; ARI2; UIP48; TRIAD1; AI843547 |
Gene ID : | 23807 |
mRNA Refseq : | NM_011790 |
Protein Refseq : | NP_035920 |
UniProt ID : | Q9Z1K6 |
Products Types
◆ Recombinant Protein | ||
ARIH2-377H | Recombinant Human ARIH2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARIH2-3441H | Recombinant Human ARIH2 protein, His-tagged | +Inquiry |
ARIH2-12359Z | Recombinant Zebrafish ARIH2 | +Inquiry |
ARIH2-4250C | Recombinant Chicken ARIH2 | +Inquiry |
ARIH2-800H | Recombinant Human ARIH2 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
ARIH2-8725HCL | Recombinant Human ARIH2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (11)
Ask a questionYes, ARIH2 has been implicated in cancer development and progression. Its dysregulation has been observed in several cancer types, and studies have shown its role in regulating the stability and activity of oncoproteins and tumor suppressors.
ARIH2 has been shown to ubiquitinate various proteins, including NEDD8-conjugating enzyme UbcH7, p53, and the EphA2 receptor, among others.
Yes, ARIH2 interacts with various proteins, including the NEDD8-conjugating enzyme UbcH7, p53, and multiple components of the immune response pathway.
Research has suggested that ARIH2 may be involved in the pathogenesis of certain diseases, including cancer and neurodegenerative disorders.
ARIH2 functions as an E3 ubiquitin ligase by binding to the target protein and facilitating the transfer of ubiquitin from the E2 ubiquitin-conjugating enzyme to the target protein.
Yes, ARIH2 has been implicated in the regulation of immune responses. It is involved in the degradation of immune signaling proteins, such as IKKγ and TRAF3, thereby modulating the activation of immune pathways.
Future research on ARIH2 aims to further elucidate its molecular mechanisms, identify additional substrates, explore its potential as a therapeutic target, and understand its role in various diseases.
Researchers employ techniques such as gene expression analysis, protein-protein interaction studies, structural biology, and molecular genetics to investigate the ARIH2 protein.
Ubiquitination by ARIH2 can lead to proteasomal degradation of the target protein, resulting in regulation of cellular processes, such as cell cycle progression, DNA repair, and immune responses.
Currently, there are no specific inhibitors or activators known for ARIH2. However, research efforts are underway to identify small molecules or compounds that can modulate its activity for potential therapeutic purposes.
Targeting ARIH2 has shown potential for therapeutic intervention, particularly in the fields of cancer treatment and neurodegenerative disease research. However, further studies are needed to fully understand its potential as a therapeutic target.
Customer Reviews (10)
Write a reviewThis flexibility ensures that the ARIH2 protein can address my specific research objectives efficiently.
Their experienced team is dedicated to resolving any issues or challenges I may encounter during my experiments, providing prompt and effective solutions.
the manufacturer's technical expertise can be advantageous to researchers.
Its purity, stability, and consistency ensure reliable and reproducible results, giving me confidence in the integrity of my research findings.
This versatility enables researchers to explore ARIH2's function and role in a range of biological processes, making it a valuable tool across diverse research fields.
With their assistance, I can overcome obstacles and optimize my experimental setup.
With the ARIH2 protein and the manufacturer's support, I am confident in obtaining accurate and meaningful results for my scientific investigations.
In addition to the advantages of ARIH2 protein itself, the manufacturer can play a crucial role in supporting the research efforts.
This quality control is essential for obtaining reliable and reproducible data, as any variability in protein quality can introduce confounding factors into experiments.
They can offer guidance on experimental design, protocol optimization, and troubleshooting, helping researchers overcome any challenges encountered during their trials.
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