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Recombinant Mouse Arih2 Protein, Myc/DDK-tagged

Cat.No. : Arih2-1700M
Product Overview : Purified recombinant protein of mouse full-length ariadne RBR E3 ubiquitin protein ligase 2 (Arih2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex. Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 57.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Arih2 ariadne RBR E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]
Official Symbol : Arih2
Synonyms : ARIH2; ariadne homolog 2 (Drosophila); E3 ubiquitin-protein ligase ARIH2; ARI-2; ariadne 2; protein ariadne-2 homolog; ubcM4-interacting protein 48; ARI2; UIP48; TRIAD1; AI843547
Gene ID : 23807
mRNA Refseq : NM_011790
Protein Refseq : NP_035920
UniProt ID : Q9Z1K6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (11)

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Is there any evidence for the involvement of ARIH2 in cancer development? 09/03/2022

Yes, ARIH2 has been implicated in cancer development and progression. Its dysregulation has been observed in several cancer types, and studies have shown its role in regulating the stability and activity of oncoproteins and tumor suppressors.

Are there any known substrates of ARIH2 protein? 10/01/2021

ARIH2 has been shown to ubiquitinate various proteins, including NEDD8-conjugating enzyme UbcH7, p53, and the EphA2 receptor, among others.

Are there any known interacting partners of ARIH2? 01/01/2021

Yes, ARIH2 interacts with various proteins, including the NEDD8-conjugating enzyme UbcH7, p53, and multiple components of the immune response pathway.

Does ARIH2 have any known disease associations? 09/14/2020

Research has suggested that ARIH2 may be involved in the pathogenesis of certain diseases, including cancer and neurodegenerative disorders.

How does the ARIH2 protein carry out ubiquitin ligase activity? 03/22/2020

ARIH2 functions as an E3 ubiquitin ligase by binding to the target protein and facilitating the transfer of ubiquitin from the E2 ubiquitin-conjugating enzyme to the target protein.

Does ARIH2 play a role in the immune response? 12/30/2018

Yes, ARIH2 has been implicated in the regulation of immune responses. It is involved in the degradation of immune signaling proteins, such as IKKγ and TRAF3, thereby modulating the activation of immune pathways.

What future directions of research are being pursued regarding the ARIH2 protein? 08/14/2017

Future research on ARIH2 aims to further elucidate its molecular mechanisms, identify additional substrates, explore its potential as a therapeutic target, and understand its role in various diseases.

What techniques are used to study the ARIH2 protein? 07/27/2017

Researchers employ techniques such as gene expression analysis, protein-protein interaction studies, structural biology, and molecular genetics to investigate the ARIH2 protein.

What are the consequences of ARIH2-mediated protein ubiquitination? 03/12/2017

Ubiquitination by ARIH2 can lead to proteasomal degradation of the target protein, resulting in regulation of cellular processes, such as cell cycle progression, DNA repair, and immune responses.

Are there any inhibitors or activators discovered for ARIH2? 11/04/2016

Currently, there are no specific inhibitors or activators known for ARIH2. However, research efforts are underway to identify small molecules or compounds that can modulate its activity for potential therapeutic purposes.

Are there any therapeutic implications of targeting ARIH2? 04/28/2016

Targeting ARIH2 has shown potential for therapeutic intervention, particularly in the fields of cancer treatment and neurodegenerative disease research. However, further studies are needed to fully understand its potential as a therapeutic target.

Customer Reviews (10)

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Reviews
01/21/2023

    This flexibility ensures that the ARIH2 protein can address my specific research objectives efficiently.

    08/12/2022

      Their experienced team is dedicated to resolving any issues or challenges I may encounter during my experiments, providing prompt and effective solutions.

      07/30/2022

        the manufacturer's technical expertise can be advantageous to researchers.

        02/16/2022

          Its purity, stability, and consistency ensure reliable and reproducible results, giving me confidence in the integrity of my research findings.

          01/30/2022

            This versatility enables researchers to explore ARIH2's function and role in a range of biological processes, making it a valuable tool across diverse research fields.

            12/07/2021

              With their assistance, I can overcome obstacles and optimize my experimental setup.

              01/03/2021

                With the ARIH2 protein and the manufacturer's support, I am confident in obtaining accurate and meaningful results for my scientific investigations.

                10/27/2020

                  In addition to the advantages of ARIH2 protein itself, the manufacturer can play a crucial role in supporting the research efforts.

                  04/16/2020

                    This quality control is essential for obtaining reliable and reproducible data, as any variability in protein quality can introduce confounding factors into experiments.

                    12/18/2017

                      They can offer guidance on experimental design, protocol optimization, and troubleshooting, helping researchers overcome any challenges encountered during their trials.

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